半叶马尾藻多糖对辐射损伤小鼠免疫功能的保护作用  

Protective Effect of Sargassum hemiphyllum(Turner) C. Ag Polysaccharides(SHP) on the Immune Function in Radiation Damaged Rats

作　　者：宋云端[1] 秦维超[1] 吕涛[1] 孟庆勇[2] 

机构地区：[1]郧阳医学院附属人民医院,湖北十堰442000 [2]广东医学院检验学院,广东湛江524023

出　　处：《时珍国医国药》2009年第8期1956-1958,共3页Lishizhen Medicine and Materia Medica Research

基　　金：广东省中医药局科研课题基金(No.2050605)

摘　　要：目的探讨半叶马尾藻多糖[Sargassum hemiphyllum(Turner)C.Ag,SHP]对辐射损伤小鼠免疫功能的影响。方法选取74MBq的32P-玻璃微球(32P-GMS)肿瘤内照射导致荷瘤小鼠辐射损伤,通过流式细胞术、分光光度法、酶释放法测定不同浓度的SHP对辐射损伤小鼠免疫功能的保护作用。结果照射组荷瘤小鼠免疫功能明显低于正常对照组(P<0.01);200,400,800 mg/kg SHP口服灌胃加照射组荷瘤小鼠免疫功能明显高于照射组(P<0.01)。结论74MBq的32P-GMS肿瘤内照射可以抑制小鼠的免疫功能,SHP对辐射损伤小鼠的免疫功能有保护作用。Objective To investigate the effect of Sargassum hemiphyllum （Turner） C. Ag polysaccharides （SHP） on the immune function in radiation damaged rats. Methods Intratumoral irration with 74MBq 32P - GMS generate radiation damage in tumor - bearing rats, and flow cytometry, photometry and lactic acid dehydrogenase release assay were adopted to detect the protective effect of different - dose SHP on the immune function in radiation damaged rats. Results Immune function of radiation group in tumor - bearing rats was obviously lower than that of normal control group （ P 〈 0.01 ）. The immune function in SHP （ 200,400,800 mg/kg） for oral use plus radiation group was obviously higher than that of normal control group（P 〈 0.01 ）. Conclusion Intratumoral irration with 74MBq ^32p _ GMS can restrain immune function in tumor -bearing rats, and SHP has protective effect on the immune function in radiation damage rats.

关 键 词：半叶马尾藻多糖 辐射损伤 免疫功能 保护作用 

分 类 号：R967[医药卫生—药理学] R811.5[医药卫生—药学]