核干细胞因子在宫颈鳞癌中的表达及意义  

Expressions of Nucleostemin protein in cervical squamous cell carcinoma and its significance

作　　者：范天黎[1] 席宇[2] 许培荣[2] 鲁照明[1] 刘红涛[2] 

机构地区：[1]郑州大学基础医学院,郑州450001 [2]郑州大学生物工程系,郑州450001

出　　处：《华中师范大学学报（自然科学版）》2009年第2期281-283,共3页Journal of Central China Normal University：Natural Sciences

基　　金：河南省医学科技攻关资助项目(20050009)

摘　　要：采用免疫组织化学方法,分析了57例宫颈鳞癌组织、39例癌旁不典型增生组织及57例正常宫颈黏膜组织中核干细胞因子(Nucleostemin,NS)蛋白的表达。结果显示:NS蛋白在正常宫颈黏膜组织、癌旁不典型增生组织及宫颈鳞癌组织中表达的阳性率依次升高,分别为15.8%、41.0%及71.9%,组间比较有显著性差异(X^2=39.015,P<0.01),此外,NS蛋白的表达与病人年龄和肿瘤直径无关(P>0.05),而与肿瘤分期、淋巴结转移和肿瘤分化具有明显的相关性(P<0.05),提示NS在宫颈鳞癌中的高表达可能与宫颈鳞癌的发生、发展密切相关,NS蛋白检测有望成为新的诊断和治疗宫颈鳞癌的重要指标。Immunohistochemical method was used to detect the expression of Nucleosterain （NS） protein in 57 cases of cervical squamous cell carcinoma （CSCC）, 39 cases of adjacent atypical hyperplasia epithelium, and 57 cases of normal cervical epithelium. The results demonstrated that the positive expression rate of NS protein in normal cervical epithelium tissues, adjacent atypical hyperplasia epithelium tissues and CSCC tissues were 15.8%, 41.0%, and 71.9%, respectively, and there was a significant difference among the 3 groups （χ2 =39. 015, P〈0.01）. In addition, the expression of NS protein was closely associated with the tumor phase, lymphatic metastasis and tumor differentiation （P〈0.05）, but not with patient＇s age and tumor diameter （P〉0. 05）, suggesting that NS may play an important role in the occurrence and development of CSCC, and the detection of NS protein may be a new important molecular marker for the diagnosis and treatment of CSCC.

关 键 词：核干细胞因子 宫颈鳞癌 免疫组织化学 

分 类 号：Q78[生物学—分子生物学]