心肌肌钙蛋白Ⅰ对环磷酰胺冲击治疗狼疮肾炎心脏毒性评估的临床意义  

Clinical assessment of cTnI in cardiac toxicity of cyclophosphamide pulse therapy for lupus nephritis

作　　者：周涛[1] 王晓云[1] 杨红英[1] 邓丹琪[1] 陈孝红[1] 梁先念[1] 高颖斐[1] 杨成凤[1] 

机构地区：[1]云南省昆明医学院第二附属医院检验科,650101

出　　处：《检验医学与临床》2009年第10期761-762,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨心肌肌钙蛋白I(cTnI)对环磷酰胺冲击治疗狼疮肾炎的心脏毒性评估的临床意义。方法应用美国贝克曼库特公司生产的进入2免疫分析系统(Access Immunoassay System2,AIS2)对环磷酰胺冲击治疗狼疮肾炎前后cTnI水平进行测定,比较治疗前后cTnI的变化,对环磷酰胺的心脏毒性进行评估。结果环磷酰胺冲击治疗前患者血清cTnI为(0.034±0.013)ng/L,冲击治疗后次日患者血清cTnI为(0.038±0.012)ng/L,冲击治疗后1周患者血清cTnI为(0.037±0.011)ng/L,冲击治疗后2周患者血清cTnI为(0.036±0.012)ng/L,以上3组结果两两比较,差别无统计学意义。结论环磷酰胺以20mg/kg剂量冲击治疗狼疮肾炎未发现有cTnI明显升高,说明该剂量冲击治疗狼疮肾炎未引起心脏毒性的发生。Objective To explore the clinical assessment of cTnI in cardiac toxicity of cyclophosphamide pulse therapy for lupus nephritis. Methods cTnI were measured before and after cyclophospbamide pulse therapy for lupus nephritis with Beckman Coulter Access Immunoassay System 2. To compare changes in cTnI before and after treatment and to make assessment of cTnI in cardiac toxicity of cyclophosphamide. Results Serum cTnⅠ before cyclophosphamide pulse therapy： （0. 034±0. 013）ng/L,serum cTnⅠ one day after treatment： （0. 038±0. 012）ng/L,serum cTnI one week after treatment： （0. 037±0. 011）ng/L,serum cTnI two weeks after treatment： （0. 0364±0. 012）ng/L,there was no significant difference among the three results. Conclusion 20mg/kg dose of cyclopbosphamide pulse therapy in lupus nephritis has not been found significantly elevated cTnⅠ,indicating that the dose of treatment of lupus nephritis can not make the occurrence of cardiac toxicity.

关 键 词：心肌肌钙蛋白I 环磷酰胺 心脏毒性 狼疮肾炎 

分 类 号：R593.241[医药卫生—内科学]