基于混合遗传算法的多信道经颅磁刺激线圈阵列设计与优化  

Coil Array Design and Optimization in Multichannel Transcranial Magnetic Stimulation Based on Hybrid Genetic Algorithm

作　　者：吕浩[1] 王旭飞[1] 唐劲天[1] 

机构地区：[1]清华大学工程物理系粒子技术与辐射成像教育部重点实验室,医学物理与工程研究所,北京100084

出　　处：《航天医学与医学工程》2009年第4期302-307,共6页Space Medicine & Medical Engineering

基　　金：国家自然科学基金资助项目(30571779;10775085);清华大学裕元医学基金资助项目;北京市科委基金资助项目(Z07000200540704)

摘　　要：目的探讨多信道经颅磁刺激技术的实现方式,以实现对具有多点同时刺激、刺激点可移动等优点的磁刺激技术的模拟仿真。方法分析圆形线圈感应电场分布规律,设计并建立了一种2×5×5的交叉型线圈阵列模型;针对优化问题设计了结合模式搜索的混合遗传算法,对交叉型线圈阵列的电流组态进行了优化。结果给出了两点刺激和三点刺激的优化结果,结果表明这种混合遗传算法具有很好的全局和局部搜索特性,在优化算法的优化下,交叉型线圈阵列可以有效逼近指定的感应电场分布。结论本文设计的线圈阵列结构和优化算法实现了经颅磁刺激中的多点刺激和刺激点移动问题,对于多信道经颅磁刺激的实现具有一定的参考借鉴意义。Objective Exploring an approach of multichannel transcranial magnetic stimulation （TMS） technique to realize simulation technique of magnetic stimulation which has excellent characteristics to stimulate synchronously multi-foci and movable foci. Methods On analyzing the distribution principles of induced electric field of round coil,a model of 2×5×5 cross-style coil array was designed and established as well as a hybrid genetic algorithm combined with pattern search was proposed to optimize the current in the coil array. Results The optimized results of two and three foci showed that this hybrid genetic algorithm had very good search property.And this coil array had the capability to produce field distribution approaching the specified field with the help of the enhanced algorithm. Conclusion The coil array design and optimization algorithms proposed in this paper will help to realize multichannel TMS.

关 键 词：多信道经颅磁刺激 线圈阵列 遗传算法 模式搜索 

分 类 号：R318.63[医药卫生—生物医学工程] TH782[医药卫生—基础医学]