风湿性心脏病单纯二尖瓣狭窄左心房内径与瓣口面积、左心房压力相关性研究  

Study on the relationship between left atrial diameter and mitral valve area or left atrial mean pressure in patients with rheumatic pure mitral stenosis

作　　者：吴玉付[1] 李醒三[2] 

机构地区：[1]广西医科大学第四附属医院心内科,广西壮族自治区柳州市545005 [2]广西医科大学第一附属医院心内科

出　　处：《中华实用诊断与治疗杂志》2009年第8期760-761,764,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的:探讨风湿性心脏病单纯二尖瓣狭窄左心房内径与二尖瓣口面积、左心房压力的关系。方法:回顾性分析242例单纯二尖瓣狭窄成功行经皮二尖瓣球囊扩张术患者临床资料,按有无心房颤动分为窦性心律组(122例)与心房颤动组(120例),分别对2组左心房内径、瓣口面积、左心房平均压力进行相关分析,并用逐步回归分析法建立多元线性回归模型。结果:窦性心律组和心房颤动组的左心房内径与瓣口面积、左心房平均压呈直线相关,瓣口面积与左心房平均压亦呈直线相关;窦性心律组得多元线性回归方程为左心房内径=52.147-6.756×瓣口面积+0.158×左心房平均压,方程检验的F值=12.346(P<0.01);心房颤动组得多元线性回归方程为左心房内径=51.609+0.179×左心房平均压,方程检验的F值=4.472(P<0.05)。结论:单纯二尖瓣狭窄瓣口面积、左心房压力是影响左心房内径的重要因素,在病程的不同阶段发挥作用不同。Objective To determine the relationship between left atrial diameter and mitral valve area or left atrial mean pressure in patients with rheumatic pure mitral stenosis.Methods Clinical data of 242 patients with rheumatic pure mitral stenosis receiving percutaneous balloon mitral valvuloplasty successfully were analyzed retrospectively.All the patients were divided into sinus rhythm group（n=122） and atrial fibrillation group（n=120） according to atrial fibrillation.Pearson correlation analysis was performed and multivariate linear stepwise regression analysis was used to check out the factors related to left atrial diameter. Results Pearson correlation analysis revealed a significant linear correlation between left atrial diameter and mitral valve area or left atrial mean pressure. A significant linear correlation was also found between mitral valve area and left atrial mean pressure both sinus rhythm group and atrial fibrillation group. Multivariate linear stepwise regression analysis showed that the left atrial diameter was 52. 147-6. 756× mitral valve area＋0. 158×left atrial mean pressure in sinus rhythm group（F= 12. 346, P〈0.01） and was 51. 609＋0. 179 × left atrial mean pressure in atrial fibrillation group （F = 4. 472, P〈0. 05）. Conelusion Mitral valve area and left atrial mean pressure in patients with rheumatic pure mitral stenosis may be the major factors of in the development of left atrial diameter, and play different roles in different period during course of diseases.

关 键 词：二尖瓣狭窄 左心房内径 瓣口面积 左心房平均压 

分 类 号：R541.2[医药卫生—心血管疾病]