AIDS患者胃黏膜病理改变与HIV感染的关系  

The relationship of pathology and HIV infection in gastric mucosal tissues from the patients with AIDS

作　　者：孙琳[1] 崔丹[2] 李冰[3] 张立洁[1] 常静[1] 祖可佳[1] 孟忻[1] 宋晨朝[1] 张世杰[1] 金荣华[4] 闫惠平[5] 

机构地区：[1]首都医科大学附属北京佑安医院病理科,北京100069 [2]首都医科大学附属北京佑安医院教育处,北京100069 [3]首都医科大学附属北京佑安医院消化二科,北京100069 [4]首都医科大学附属北京佑安医院药理基地,北京100069 [5]首都医科大学附属北京佑安医院感染与免疫中心,北京100069

出　　处：《胃肠病学和肝病学杂志》2009年第8期724-727,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：北京市科技计划重大项目资助(H020920020290)

摘　　要：目的探讨AIDS患者胃黏膜病理改变与HIV感染的关系。方法选取AIDS期HIV慢性感染患者25例,PCR法制备地高辛标记HIV-1-LTR、gag基因的双链cDNA探针,对胃黏膜组织切片采取核酸原位杂交方法观察HIV感染情况和黏膜病理改变。结果AIDS患者胃黏膜主要表现为慢性浅表性胃炎(CSG)和慢性萎缩性胃炎(CAG)。且AIDS患者胃黏膜组织多种细胞中均有HIV阳性显色:淋巴滤泡细胞、固有层中散在的单个核细胞(似淋巴细胞和巨噬细胞)、胃黏膜上皮细胞、腺上皮细胞、极少数间质细胞。CSG组与CAG组胃黏膜HIV的阳性表达率无明显差异(P>0.05)。结论HIV/AIDS疾病的进程与胃黏膜局部病理改变之间可能存在一定关联性,但HIV感染可能并非发挥重要作用。Objective To investigate the relationship of pathology and HIV infection in gastric mucosal tissues from the patients with AIDS. Methods Twenty-five patients in AIDS stage of HIV-infected patients were enrolled. The labeled HIV-1 double-stranded cDNA probe was a PCR product corresponding to the LTR and gag gene of the HIV-1 genome. In situ hybridization （ISH） test was used to detect HIV in gastric mueosal tissues of AIDS patients. Results It showed chronic superficial gastritis （CSG） and chronic atrophic gastritis （CAG） in gastric mucosal pathology of AIDS patients. HIV gene sequence mainly located gastric mucosal mononuclear cell （MMC） , other cells also were observed with HIV expression including mucosal epithelial cells, gland epithelial cells and interstitial cells. There was no difference between HIV expression in the CSG and CAG （P 〉 0.05）. Conclusion The connection of the AIDS process and pathology in gastric mucosal tissues is possible, but HIV infection may not produce a marked effect.

关 键 词：胃黏膜 HIV感染 病理改变 

分 类 号：R512.91[医药卫生—内科学]