2007年中国CHINET肠杆菌属耐药性监测  

CHINET 2007 surveillance of antibiotic resistance in Enterobacter spp in China

作　　者：李丽[1] 童先丽[1] 田磊[1] 张蓓[1] 简翠[1] 孙自镛[1] 徐英春[2] 孙宏莉[2] 俞云松[3] 杨青[3] 张泓 李万华 胡云健[5] 艾效曼[5] 倪语星[6] 孙景勇[6] 魏莲花[7] 吴玲[7] 汪复[8] 朱德妹[8] 胡付品[8] 阮斐怡[8] 贾蓓[9] 黄文祥[9] 王传清[10] 薛建昌[10] 卓超[11] 苏丹虹[11] 张朝霞[12] 季萍[12] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030 [2]中国医学科学院,中国协和医科大学附属协和医院 [3]浙江大学医学院附属第一医院 [4]上海交通大学附属儿童医院 [5]卫生部北京医院 [6]上海交通大学医学院附属瑞金医院 [7]甘肃省人民医院 [8]复旦大学附属华山医院抗生素研究所 [9]重庆医科大学附属第一医院 [10]复旦大学附属儿科医院 [11]广州医学院附属第一医院 [12]新疆医科大学附属第一医院

出　　处：《中国感染与化疗杂志》2009年第3期201-206,共6页Chinese Journal of Infection and Chemotherapy

摘　　要：目的了解2007年我国不同地区12所教学医院肠杆菌属细菌的临床分布和耐药状况。方法全国12所教学医院2007年1—12月临床分离的1231株肠杆菌属细菌,采用K-B法进行药物敏感性试验,以CLSI2007版为判断标准。结果临床分离的1231株肠杆菌属细菌分离于呼吸道分泌物745株(60.5%)、尿液147株(11.9%)、血液66株(5.4%)和脑脊液11株(0.9%),其他无菌体液(胆汁、胸腹水等)39株(3.2%)。肠杆菌属细菌对头孢西丁耐药率最高(93.0%);对头孢噻肟和头孢他啶的耐药率较高(36.9%～37.7%);对头孢吡肟、阿米卡星、庆大霉素和环丙沙星耐药率较低(13.7%～28.0%);对亚胺培南和美罗培南耐药率最低,仅为0.9%。结论肠杆菌属细菌的耐药情况日趋严重,尤其是新出现了碳青霉烯类抗生素耐药株,各医院应采取相应的控制措施以遏制耐药株的增长。Objective To investigate the distribution and antibiotic resistance clinical Enterobacter isolates. Methods A total of 1 231 clinical strains of Enterobacter spp were collected from 12 hospitals during January 1 through December 31, 2007. Antimicrobial susceptibility testing was performed with Kirby-Bauer method. The results were analyzed accord： ing to CLSI 2007 standards. Results The main source of Enterobacter was sputum （60. 5%, 745/1 231） and urine （11.9%, 147/1 231）, blood （5.4%, 66/1 231）, and cerebrospinal fluid （0. 9%, 11/1 231） followed by aseptic body fluid （3.2%, 39/1 231）. The resistance rate （93.0%） to cefoxitin was the highest. The rate of resistance to cefotaxime, and ceftazidime, was relatively higher （36. 9% to 37.7%）. However, the rate of resistance to cefepime, amikacin, gentamicin and ciprofloxacin was relatively lower （13.7% to 28.0%）. The rate of resistance to imipenem and meropenem was the lowest （0.9%）. Conclusions Antibiotic resistance of Enterobacter spp is serious in China. Especially, earbapenemsresistant Enterobacter isolates were identified. Every hospital should take effective control measures to curb the growth of resistant strains.

关 键 词：肠杆菌属 阴沟肠杆菌 产气肠杆菌 碳青霉烯类 抗感染 耐药性 

分 类 号：R446.5[医药卫生—诊断学]