首发精神分裂症患者血浆同型半胱氨酸水平的研究  

Study of Plasma Homocysteine Level in First-episode Schizophrenia

作　　者：杨东英[1] 卢芸凌[1] 薛立庆[1] 陆小兵[1] 杨梦心[1] 童梓顺[1] 

机构地区：[1]中国.广州市精神病医院,510370

出　　处：《中国健康心理学杂志》2009年第7期776-777,共2页China Journal of Health Psychology

基　　金：广州市医药卫生科技项目(2005-YB-098)

摘　　要：目的观测首发精神分裂症患者血浆同型半胱氨酸水平,并探讨其与精神病理症状的关系。方法采用荧光偏振免疫法(FPIA)检测100例首发精神分裂症患者(患者组)和100例健康正常人(对照组)的血浆Hcy水平并比较,并结合阳性和阴性症状量表(PANSS)总分及各因子分进行相关分析。结果患者组血浆Hcy水平(16.24±7.67μmol/L)高于对照组(10.41±4.51μmol/L),其高同型半胱氨酸血症(HHcy>15μmol/L)的发生率明显高于对照组(χ2=13.2,P<0.05)。Hcy水平与PANSS总分及阴性症状总分呈正相关(r=0.48/0.45,P<0.05)。结论首发精神分裂症患者的血浆Hcy水平升高,高Hcy水平与精神病理症状(特别是阴性症状)有关。Objective To observe plasma homocysteine level of first-episode schizophrenia and explore the correlation between plasma homocysteine level and psychopathic symptom. Methods The plasma bomocysteine level was measured by fluorescence po- larization immunoassay （FPIA） in case-control study including 100 first-episode schizophrenic patients and 100 healthy controls, and the correlation between the plasma homocysteine level and PANSS score were explored. Results The plasma HCY level （16. 24±7.67） was significantly higher in patients group than that of the control （10. 41±4.51pmol/L, P〈0. 05）. The case with hy- perhomocysteine was much more in patients group than that in the control （X2= 13. 2, P〈0.05）. The plasma homocysteine level positively correlated to the PANSS total score and the negative symptom total score. Conclusion The plasma HCY level in first- episode schizophrenia was high and the high homocysteine level was related with psychopathic symptom, especial the negative symptom.

关 键 词：首发精神分裂症 同型半胱氨酸 荧光偏振免疫法 

分 类 号：R971.4[医药卫生—药品] R587.1[医药卫生—药学]