CCR5基因多态性与乙型肝炎病毒感染相关性的研究进展  

Genetic Association of CCR5 Polymorphisms with HBV Infection

作　　者：谭奎[1] 单可人[1] 任锡麟[1] 

机构地区：[1]贵阳医学院分子生物学重点实验室,550004

出　　处：《国际遗传学杂志》2009年第4期294-297,共4页International Journal of Genetics

基　　金：贵州省科技厅科技计划课题（黔科合SY字[2008]3053）;贵州省省长基金（黔科教办[2005]14号）;贵州省科技厅科研基金项目（黔科合J字[2005]2016号）;贵州省科技厅科研基金项目（黔科合J字[2007]2032）

摘　　要：趋化性细胞因子和趋化性细胞因子受体在抗病毒免疫中发挥了重要作用。乙型病毒性肝炎是由其表达的抗原系统及其抗体所介导的特异性免疫反应和非特异性的以细胞因子为主的炎症介质导致的肝细胞损伤。CCR5作为趋化性细胞因子受体在乙型病毒性肝炎的发生发展中起重要作用。本文主要讲述CCR5的结构和功能及该基因在编码区和启动子区的多态性与HBV感染的相关性研究。Chemokine and chemokine receptor play an important role in anti-virus immunity system. Hepatitis B is caused by the injured liver cell that is led by specific immune response of the expression of antigen system and antibody system, and by non-specific immune response of specific cytokines mainly to the cell factors. CCR5, as a chemokine, plays an important role in the occurrence and development of hepatitis B. This article introduces the CCR5 gene structures and functions, and the relevance between the polymorphism of HBV in the coding region and the promoter region and HBV infection.

关 键 词：趋化性细胞因子受体5 基因多态性 乙型肝炎病毒感染 

分 类 号：R51[医药卫生—内科学]