冠脉宁片对犬急性心肌缺血的保护作用研究  

Effect of Guanmaining Tablet on Acute Myocardial Ischemia in Dogs

作　　者：孟庆玉[1] 魏云[1] 郑兵[1] 彭志辉[1] 吴爱萍[1] 

机构地区：[1]湖南医药工业研究所,长沙410014

出　　处：《中国药师》2009年第9期1182-1184,共3页China Pharmacist

摘　　要：目的:观察冠脉宁片对犬急性心肌缺血的保护作用。方法:制备犬实验性急性心肌梗死模型后,十二指肠给药,阳性对照组给予丹参滴丸0.04g·kg^(-1);实验低、中、高剂量组分别给予冠脉宁片相当于生药0.3,0.6,1.2g·kg^(-1),考察心肌缺血范围、心肌缺血程度、血清酶学变化和心肌代谢物的变化。结果:冠脉宁片可改善心肌缺血程度,缩小心肌缺血范围,降低血清磷酸肌酸激酶和乳酸脱氢酶的活性,减少乳酸、游离脂肪酸和过氧化脂质的量。结论:冠脉宁片对犬急性心肌缺血具有一定的保护作用。Objective： To study the effect of Guanmainin （GMN） tablet on myocardial ischemia and myocardial infarction in dogs. Method： Dog models （n = 30） with acute ischemia were prepared by ligation the left anterior descending coronary arteries, The dogs were divided four groups, the positive control group with radix salviae miltiorrhizae dropping pills 0.04g· kg^-1 was given, the experiment high, medium, lowe doses groups with GMN tablet 0.3,0.6,1.2g·kg^-1 were given ,respectively. The anti-myocardial ischemia action was assessed,the changes in myocardial infarction size, and degree of myocardial infarction, the changes in serum serokinases and myocardial metabolism were determined. Result： GMN tablet decreased the activities of serum creatine phosphokinase and lactate dehydrogenase, reduced the content of lactic acid / free fatty acid/lipid peroxidation, improved myocardial ischemia and reduced the myocardial infarction area. Conclusion： GMN tablet play a prominent protective effect on myocardial ischemia in dogs.

关 键 词：冠脉宁片 心肌缺血 磷酸肌酸激酶 乳酸脱氢酶 过氧化脂质 

分 类 号：R285.5[医药卫生—中药学]