检测视黄醇蛋白和微量白蛋白及IV型胶原对糖尿病肾病早期诊断的意义  

Significance of detecting retinol binding protein, micro albumin and type IV collagen for early diagnosis of diabetic nephropathy

作　　者：魏宏强 

机构地区：[1]黑龙江省大庆铁路医院

出　　处：《中国病案》2009年第9期48-48,F0003,共2页Chinese Medical Record

摘　　要：目的探讨尿标本中视黄醇结合蛋白(RBP)、微量白蛋白(mALB)、IV型胶原(IV-C)检测在糖尿病肾病早期诊断中的作用。方法用ELSA法检测尿中RBP、IV-C,免疫比浊法检测mALB,Jaffe法测定肌酐。结果正常对照组RBP/Cre及IV-C的含量分别为2.12±0.95mg/mmol、44.68±17.2ng/ml。在糖尿病无肾病组中,mALB的含量与正常对照组相近(P>0.05),而RBP、IV-C的含量与正常对照组相比有显著差别(P<0.05)。糖尿病的初期肾病组和临床肾病组的RBP/Cr、mALB、IV-C的含量均明显高于对照组(P<0.01)。结论联合检测尿RBP、IV-C是诊断糖尿病肾病早期损伤灵敏、可靠的实验室指标。Objective To explore and discuss the role of detecting retinol binding protein （RBP）, micro albumin （mAlb）, type Ⅳ collagen （Ⅳ-C） of urine specimens in early diagnosis of diabetic nephropathy. Method Detecting urine RBP, Ⅳ-C by ELISA, assaying mALB through immunity turbidimetry method and measuring Creatinine （Cre） by Jaffe method. Result RBP/Cre and Ⅳ-C content of normal control group is 2.12 ＋ 0.95 mg/mmol and 44.68 ＋ 17.2 ng/ml, respectively, mAlb content of diabetic nephropathy group is similar with normal control group（P 〉 0.05）. However, RBP and Ⅳ-C content of diabetic ncphropathy group showed significant difference compared with normal control group（ P 〈 0.05 ）. RBP/Cr, mAlb and Ⅳ-C content of both initial stage nephropathy in diabetes group and clinical nephropathy group is significantly higher than control group （P 〈 0.01）. Conclusion Combination of detecting urine RBP, Ⅳ-C and mAlb is a sensitive and reliable parameter to diagnose early damage of diabetic nephropathy.

关 键 词：糖尿病肾病 视黄醇蛋白 Ⅳ型胶原 

分 类 号：R587.2[医药卫生—内分泌] R734.2[医药卫生—内科学]