含磺酰胺基和羧苯基的异方酰胺的合成  

Synthesis of Isosqurarylium Amides Containing N' - Substituted Sufamoyl Phenyl and Carboxy Phenyl Groups

作　　者：李聚才[1] 周海兵[1] 陈益钊[1] 

机构地区：[1]四川大学化学系,成都610064

出　　处：《有机化学》1998年第4期337-341,共5页Chinese Journal of Organic Chemistry

摘　　要：以3-[邻(或对)羧苯胺基]-4羟基-3-环丁烯二酮(1a,1b)为底物,与一些磺胺反应,成功地制得了14个新的不对称取代的异方酰胺。3a～3f和4a～4f结构上的共同特点是,有药物作用的磺酰胺和邻(或对)氨基苯甲酸的结构单元,通过方酸四碳环的桥接作用而共存于同一分子之中。Fourteen new asymmetric substituted isosqurarylium amides were successfully obtained by the reaction of 3 - [ ortho - (or para - ) carboxy anilino] - 4 - hydroxy - 3 - cyclo - butenedione with some sulfanilamides. The common marked characteristic of the structure of these compounds 3a - 3f and 4a - 4f is that the structure units with medicinal effective sulfanilamide and ortho - (or para - ) benzaminic acid existed in the same molecule through the bridging of the tetracarbon ring of squaric acid.

关 键 词：磺胺 氨基苯甲酸 异方酰胺 环丁烯二酮 合成 

分 类 号：O624.5[理学—有机化学]