新型血管紧张素转化酶抑制剂——氮杂三肽类似物的合成及结构活性关系  

Novel Angiotensin Converting Enzyme Inhibitors——Synthesis and Structure-Activity Relationship of Azatripeptide Analogs

作　　者：刘世峰[1] 徐杰诚[1] 

机构地区：[1]中国科学院上海有机化学研究所,上海200032

出　　处：《化学学报》1998年第7期707-713,共7页Acta Chimica Sinica

基　　金：国家自然科学基金(29232042);生命有机化学国家重点实验室资助项目

摘　　要：设计与合成一系列氮杂三肽类似物,测定了氮杂三肽类似物对血管紧张素转化酶的体外抑制活性,探讨了它们的结构与抑制活性之间的关系,结果表明氮杂丙氨酸是丙氨酸很好的替代物.A series of azatripeptide analogs were designed and synthesized. The in vitro inhibitory activities of these compounds toward angiotensin converting enzyme (ACE) were evaluated. Furthermore,the structure - activity relationship of these compound was discussed. The results showed that azaalanine was a good isosterer of alanine in angiotensin converting enzyme inhibitors.

关 键 词：血管紧张素 转化酶 降压药 氮杂三肽 抑制剂 ACE 

分 类 号：TQ463.53[化学工程—制药化工]