钒取代杂多钨酸盐抗伪狂犬病病毒的活性  

Activity of Vanadium-substituted Heteropolytungstate to Antipseudorabies Virus

作　　者：刘杰[1] 涂长春[2] 张茂林[2] 侯世宽[2] 王恩波[1] 

机构地区：[1]东北师范大学化学系,长春130024 [2]解放军农牧大学军事兽医研究所

出　　处：《应用化学》1998年第4期41-44,共4页Chinese Journal of Applied Chemistry

基　　金：国家科委资助

摘　　要：合成了10种钒取代的杂多钨酸盐，采用细胞培养法，测定了各化合物对兔肾（RK）细胞的毒性及在无毒浓度下，抗伪狂犬病病毒（PRV）的活性，结果表明，部分化合物在无毒浓度下，具有较强的抗伪狂犬病病毒的活性．其中3种化合物显示出相当高的效力和选择性，半有浓度为3．5～5.0mg/L，半中毒浓度在400～420mg/L之间，化合物的浓度在25mg/L时，对伪狂犬病病毒的抑制作用达70％～80％，病毒的感染滴度TCID50下降4个对数．对其构效关系以及抗病毒机理也作了初步探讨．Some vanadium-substituted hetropolytungstates were synthesized. Their toxicityto the cells of RK and activity to antipseudorabies virus at nontoxic concentrations were tested by cell-culture methods. The results showed that some of the compounds had high antiPRV activity at nontoxic concentration. Among them three had high antivirus and selectiveactivity with median effective concentration 3.2～5. 0 mg/L and cell median toxicity concentration 400～420 mg/L. At concentration of the compounds 12. 5 mg/L the inhibition toPRV was more than 70%～80%, while virus TCID50 values descended four log. The relationbetween the structure and activity has been discussed briefly.

关 键 词：钒取代杂多钨酸盐 合成 抗病毒活性 伪狂犬病病毒 

分 类 号：R978.7[医药卫生—药品]