伊班膦酸钠干预绝经后骨质疏松骨量的研究  

Efficacy of monthly oral ibandronate in the treatment of postmenopausal bone loss

作　　者：包丽华[1] 林华[2] 李永军[1] 朱秀芬[2] 张克勤[1] 徐兆强[1] 

机构地区：[1]南京医科大学第一附属医院,南京210029 [2]南京大学医学院附属鼓楼医院骨病中心

出　　处：《中国骨质疏松杂志》2009年第8期587-589,共3页Chinese Journal of Osteoporosis

摘　　要：目的评价伊班膦酸钠对绝经后骨质疏松骨量变化的作用。方法32例年龄47～80岁的绝经后骨质疏松妇女,腰椎、股骨颈或股骨总量骨密度T值≤-2.5SD,予以口服伊班膦酸钠150mg,每月1次,每天服用钙剂0.5g,治疗时间1年,治疗前后测量腰椎及髋部骨密度,评价伊班膦酸钠对绝经后骨质疏松骨量变化的作用。结果伊班膦酸钠治疗半年后,患者腰椎骨量较治疗前显著升高（P＆lt;0.05）,未见明显不良反应,患者有较好的耐受性和持续性。结论伊班膦酸钠治疗绝经后骨质疏松能显著改善患者骨量,临床使用安全、方便。Objective To determine the efficacy of ibandronate in the treatment of postmenopausal osteoporosis. Methods This study enrolled 32 postmenopausal women aged 47- 80 years with BMD at baseline lumbar spine or femoral neck or total hip T-score ≤ -2.5. Subjects received 150 mg monthly oral ibandronate and took calcium 0.5 g/d. Responder analyses examined the percentage of participants with changes from baseline BMD in lumbar spine and femoral neck and total hip. Results Subjects treated with ibandronate achieved larger increasers（ P 〈 0.05）, in lumbar spine BMD after an half year compared with treatment before. Treatment regimens were well tolerated and persisted. Conclusion Monthly roal ibandronate is an effective and convenient medication for postmenopausal osteoporosis.

关 键 词：骨质疏松 骨密度 伊班膦酸钠 治疗 

分 类 号：R681[医药卫生—骨科学] R730.5[医药卫生—外科学]