绝经后骨质疏松骨量与血脂利塞膦酸钠干预的研究  

The related variety analysis of bone mineral density and blood lipid in postmenopausal osteoporosis patients with risedronate treatment

作　　者：林华[1] 陈新[1] 张咏梅[1] 朱秀芬[1] 

机构地区：[1]南京大学医学院附属鼓楼医院骨病中心

出　　处：《中国骨质疏松杂志》2009年第8期590-592,589,共4页Chinese Journal of Osteoporosis

基　　金：南京市医学科技重点发展基金资助项目(ZKG9913)

摘　　要：目的研究分析绝经后骨质疏松患者骨量与血脂在利塞膦酸钠干预前后的变化。方法120例绝经后骨质疏松妇女,随机分为两组,利塞膦酸钠治疗组（利塞膦酸钠,5mg/天,口服）和安慰剂对照组（安慰剂,每天1片）,服用时间为早餐前30分钟与150ml水同时服用,服药后30分钟内不能卧床;所有患者每天补充钙剂500mg和维生素D200IU。腰椎和髋部骨量双能X骨密度测量和血脂检测分别于治疗前和治疗12个月时进行。结果两组腰椎骨密度及总胆固醇、低密度脂蛋白差值差异有显著性（P＆lt;0.05）,利塞膦酸钠治疗组腰椎骨密度上升值、总胆固醇及低密度脂蛋白下降值均高于安慰剂组（P＆lt;0.05）;股骨近端总骨密度、Ward三角骨密度及甘油三脂、高密度脂蛋白两组间差异无显著性。结论绝经后骨质疏松患者经利塞膦酸钠干预1年,腰椎骨密度显著上升,血总胆固醇和血低密度脂蛋白显著性下降。Objective To study the variety of bone mineral density（BMD） and blood lipid in postmenopausal osteoporosis patients with risetronate treatment. Methods 120 postmenopausal osteoporosis patients were randomly divided into two groups, Treatment group 60 patients were treated by risedronate sodium （5 mg/tablet） and Control group 60 patients were treated by same tablets which had no risedronate sodium. All patients took one tablet per day half an hour before breakfast with 150ml water. After that, patients should not lie down within 30 minute. Before going to bed, all patients took one tablet of Calcichew D which including 500 mg calcium and 200IU VitD. The dural-energy X-ray absorptiometry was performed to measure the BMD on lumbar vertebrae and hip as well as the indexes of blood lipid was also investigated before and after 12 months of medication, respectively. Results The cholesterol and LDL-C of patients in Treatment group were significantly lower than those of patients in Controi group（ P 〈 0.05）, and the BMD of lumbar vertebrae of patients in Treatment group were significantly higher than those of patients in Control group; The BMD of hip and TG as well as HDL-C showed no significant difference between the two groups. The increasing values of BMD of lumbar vertebrae of patients in Treatment group was higher than those of patients in Control group and the decreasing values of cholesterol and LDL-C of patients in Treatment group were significantly higher than those of patients in Control group （ P 〈 0.05）. Conclusion After risedronate sodium treatment, the BMD of lumbar vertebrae of osteoporosis patients had increased and the TC, LDL-C of these patients had decreased.

关 键 词：骨质疏松 骨密度 血脂 利塞膦酸钠 

分 类 号：R58[医药卫生—内分泌]