骨转换生化标志物及其应用研究进展  

Biochemical markers of bone turnover and their applications

作　　者：邢学武[1] 向川[1] 卫小春[1] 

机构地区：[1]山西医科大学第二医院骨科,骨与软组织损伤修复山西重点实验室

出　　处：《中国骨质疏松杂志》2009年第8期610-617,共8页Chinese Journal of Osteoporosis

基　　金：国家自然基金资助项目(30371440,30500515);山西省自然科学基金资助项目(20041117,2006021045)

摘　　要：骨重建是一个骨吸收和骨形成的过程,而该过程中的骨吸收和骨形成分别由破骨细胞和成骨细胞介导。骨转换加速是骨代谢疾病发生的重要原因,细胞活动耦联的中断伴随骨转换加速过程。在过去几十年中,一直致力于对可以反映骨转换的生化标志物的研究。大量研究表明,血清或尿液中的生化标志物与骨丢失率和骨折风险相关,这对于高风险患者的确定有重要意义。笔者对近年来骨转换生化标志物及其临床应用研究进展进行综述,特别关注其在药物功效的临床试验和骨量测量的补充这两方面的应用。有针对性地运用生化标志物可以进一步优化高风险患者的确定、药物开发的过程以及骨质疏松症治疗疗效的临床监测。虽然生化标志物有各种各样的变异性,但必将以其无创性、易重复性和及时性的优点而被广泛运用。Bone is a metabolically active tissue that undergoes continuous remodelling by two counter acting processes, namely bone formation and bone resorption. These processes rely on the activity of osteoclasts, osteoblasts and osteocytes. Acceleration of bone turnover, accompanied with a disruption of the coupling between these cellular activities, plays an established role in the pathogenesis of metabolic bone diseases, such as osteoperosis. In the past few decades, Many research has been working on biochemical markers which may reflect the rate of bone turnover. A large number of studies have shown that serum or urine biochemical markers are related to bone loss and fractures, which is important to identify high-risk patients. The aim of the review is to give an update on biochemical markers of bone turnover and their applications in recent years, with special attention to their applications in clinical trials testing the efficacy of drugs and how they supplement the measurement of bone mass. Targeted use of biochemical markers can be further optimized to identify high-risk patients, the process of drug development and clinical monitoring of the efficacy of osteoporosis treatment. Although biochemical markers have a wide range of variability, They are bound to be used widely because of their advantages of non-invasive, easy repeatability and timeliness.

关 键 词：骨形成标志物 骨吸收标志物 骨密度 骨质疏松症 检测及治疗 

分 类 号：R681[医药卫生—骨科学]