猪主动脉根部构型对无支架瓣设计的意义研究  

Study on the influence of the configuration of porcine aortic root on the stentless valve design

作　　者：吴帆[1] 魏旭峰[1] 易定华[1] 谭红梅[1] 徐殊[1] 刘维永[1] 

机构地区：[1]第四军医大学西京医院心血管外科,西安710032

出　　处：《中华外科杂志》2009年第17期1336-1339,共4页Chinese Journal of Surgery

基　　金：国家863计划资助项且（2006AA02A138）

摘　　要：目的研究猪主动脉根部构型的内在关系，为无支架主动脉瓣膜设计提供参考。方法测量和计算新鲜的和经环氧氯丙烷改性戊二醛处理的猪主动脉根部（各20只）在4个水平的管口面积（OA1～4），瓣叶平均面积（Sa），瓣叶面积模拟量（AA，AA=1／2PH），瓣叶面积模拟量均值（AAa），左、右、无冠状动脉瓣PH值（PHI、PHr、PHn）和左、无冠状动脉瓣PH值之和（PHln），利用线性相关回归分析方法观察两组瓣膜sa和AAa，OA和Sa，OA和AAa，PHI、PHr和PHn，PHln和PHr之间的相关关系。结果新鲜组和处理组瓣膜的Sa和AAa之间相关系数分别为0．886和0．872（P〈0．05）；新鲜组瓣膜OA1～4和AAa之间相关系数分别为0．810、0．851、0．900和0．815（P〈0．05），处理组为0．852、0．888、0．836和0．817（P〈0．05）；表明瓣叶面积模拟量均值和瓣叶面积、管口面积之间相关性较高。另外，处理组瓣膜PHln和PHr之间满足线性回归方程：PHr=-1．665＋0．688PHln（r=0．907，P〈0．05），用PHln能较好地预测PHr。结论瓣叶PH值能较好地提示主动脉根部的空间构型并为无支架生物瓣膜设计提供一个可供参考的指标。Objective To provide the reference for the stentless aortic valve design with the study of the inner configuration of porcine aortic root. Methods The orifice areas of porcine aortic root at 4 levels （ OA1 to 4）, the average area of leaflets （Sa） , the area analogue of leaflets （ AA, AA = 1/2PH ） , the average area analogue of leaflets（AAa） , the value PH of the left, right, non coronary leaflets（ PH1, PHr, PHn） and the sums of PHs of the left and non-coronary leaflets （PHln） in the fresh and glutaraldehyde and epichlorohydrin-treated porcine aortic valves （20 respectively） were measured and calculated. The linear correlation and regression analysis by SPSS 12. 0 was used to analyze the correlation between Sa and AAa, OA and Sa, OA and AAa, PH1, PHr and PHn, PHln and PHr in both groups. Results The coefficient correlation between Sa and AAa in fresh and treated groups were 0. 886 and 0. 872 respectively （P 〈 0.05 ）. The coefficient correlation between OA1 to 4 and AAa were 0. 810, 0. 851, 0. 900, and 0. 815 respectively in fresh group （P 〈0. 05）, and were 0. 852, 0. 888, 0. 836, and 0. 817 respectively in treated group （P 〈 0. 05）. This showed that the degree of correlation between the average area analogue of leaflets and the average area of leaflets, the orifice areas of aortic root were relatively large. Additionally, the equation of linear regression existed between PHln and PHr in treated group as follows： PHr = -1. 665 ＋ 0. 688PHln （ r = 0. 907, P 〈 0. 05 ）, thereby PHr could be predicted by PHln. Conclusion The value of PH of leaflets could represent the spatial configuration of the aortic root, which provided a referred index for the stentless bioprostheses design.

关 键 词：主动脉瓣 假体和植人物 组织工程 

分 类 号：R686[医药卫生—骨科学]