术前应用盐酸戊乙奎醚对老年患者术后早期认知功能的影响  

Effect of penehyclidine on cognitive function early after surgery in the elderly

作　　者：疏树华[1] 潘建辉[1] 方才[1] 王瑞明[1] 谢志琼[1] 

机构地区：[1]安徽医科大学附属省立医院麻醉科,合肥市230001

出　　处：《临床麻醉学杂志》2009年第8期658-660,共3页Journal of Clinical Anesthesiology

基　　金：安徽省卫生厅临床医学重点学科应用技术项目(编号:05A026)

摘　　要：目的观察术前应用盐酸戊乙奎醚对老年全麻患者术后早期认知功能障碍(POCD)的影响。方法择期全麻下行非心脏手术老年患者(≥65岁)120例,随机均分成三组,麻醉前30min分别肌注盐酸戊乙奎醚0.5mg(A组)、阿托品0.5mg(B组)或东茛菪碱0.3mg(C组),于术前24h及术后24、48、72h由同一测试者采用简易智力状态检查法(MMSE)评估患者认知功能。结果手术后3d内A、B和C组POCD发生率分别为25%、27.5%和30%,三组间差异无统计学意义。术后24、48和72hMMSE评分A组略高于B组和C组。结论术前肌注盐酸戊乙奎醚0.5mg不增加老年非心脏手术患者POCD发生率。Objective To observe the effect of penehyclidine on cognitive dystunetion early alter noncardiac surgery in the elderly. Methods One hundred and twenty patients older than 65 years old scheduled for selective the noncardiac surgery were randomly divided into three groups with 40 cases each,who were given irn. penehyelidine 0.5 mg（group A）, atropine 0. 5 mg（group B） and scopolamine 0.3 mg（group C）, respectively, 30 min before anesthesia. The cognitive function was evaluated by mini-mental state examination （MMSE） before operation and at 24,48,72 h after operation. Results The incidences of post operative mini-mental state examination cognitive dysfunction（POCD） were 25% in group A, 27.5% in group B and 30% in group C. The score of MMSE in group A was slightly higher than that in groups of B and C at 24, 48 and 72 h after operation. Conclusion Preoperative administration of penehyclidine 0. 5 mg does not increase the incidence of POCD in the elderly early after noncardiac surgery.

关 键 词：盐酸戊乙奎醚 术后认知障碍 老年 

分 类 号：R614[医药卫生—麻醉学]