半边莲化学成分的研究  

Chemical constituents of Lobelia chinensis

作　　者：韩景兰[1,2] 张凤岭 李志宏[1] 杜冠华[1] 秦海林[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所中草药物质基础与资源利用教育部重点实验室,北京100050 [2]郑州大学第五附属医院,河南郑州450002 [3]新乡市中医院,河南新乡453000

出　　处：《中国中药杂志》2009年第17期2200-2202,共3页China Journal of Chinese Materia Medica

摘　　要：目的：研究半边莲Lobelia chinensis Lour.全草的化学成分。方法：用溶剂提取、萃取、硅胶正相柱色谱及结晶法进行化学成分的分离纯化，通过理化性质和波谱分析鉴定结构。结果：从半边莲全草中分离鉴定了7个化合物，结构分别为：5-羟基-4′ -甲氧基黄酮-7-O-芸香糖苷（1），正丁基-O-β-D-吡喃果糖苷（2），5，7-二甲氧基香豆精（3），cirsiumaldehyde（4），香叶木素（5），5-hydroxymethyl-2-furancarboxaldehyde（6）和6-羟基-7-甲氧基香豆精（7）。结论：化合物2～4，6，7为首次从该植物中分离得到。Objective： To study the chemical constituents from Lobelia chinensis. Method： The constituents were extracted with 95% EtOH, partitioned with different solvents, and isolated and purified by silica gel column chromatography and crystallization, their structures were elucidated by physico-chemical properties and spectroscopic data. Result： Seven compounds were isolated from the titled plant. They were identified as 5-hydroxy-4′-methoxyflavone-7-O-rutinoside （1）, n-butyl-O-β-D-fructopyranoside （2）, 5,7-dimethoxycoumarin （3）, cirsiumaldehyde （4）, diosmetin （5）, 5-hydroxymethyl-2-furancarboxaldehyde （6）, and 6-hydroxy-7-methoxycoumarin （7）. Conclusion： Compounds 2-4, 6, and 7 were obtained from the titled plant for the first time.

关 键 词：半边莲 全草 化学成分 

分 类 号：R284.1[医药卫生—中药学] R282.71[医药卫生—中医学]