甲状腺功能亢进症合并肺动脉高压患者血浆尾加压素Ⅱ的变化及意义  

Clinical significance of change of plasma urotensin Ⅱ in the hyperthyroidism patients with pulmonary hypertension

作　　者：柴国禄[1] 谭丽艳[1] 宋静[1] 张尧杰[1] 

机构地区：[1]佳木斯大学附属第一医院内分泌科,黑龙江佳木斯154003

出　　处：《中国现代医学杂志》2009年第16期2491-2493,共3页China Journal of Modern Medicine

摘　　要：目的探讨甲状腺功能亢进症(甲亢)合并肺动脉高压患者血浆尾加压素Ⅱ(UⅡ)、肾上腺髓质素(ADM)水平的变化。方法测定58例单纯甲亢患者,30例甲亢合并肺动脉高压患者和30例正常对照组血浆UⅡ、ADM水平,分析血浆UⅡ、ADM变化与甲亢合并肺动脉高压的关系。结果甲亢合并肺动脉高压患者血浆UⅡ、ADM水平较单纯甲亢患者明显升高(均P<0.01),甲亢合并肺动脉高压患者血浆UⅡ、ADM水平与患者肺动脉压呈明显正相关(r=0.496,r=0.483,均P<0.01)。结论血浆UⅡ、ADM水平升高在甲亢合并肺动脉发生的病理生理过程中发挥重要作用。[ Objective ] To explore the change of plasma urotensin Ⅱ （U Ⅱ ） and adrenomedullin （ADM） in the hyperthyroidism patients with pulmonary hypertension. [Methods] The concentrations of U Ⅱ and ADM were measured in 58 hyperthyroidism patients without pulmonary hypertension,30 hyperthyroidism patients with pulmonary hypertension and 30 normed individuals. The relationship between plasma levels of U Ⅱ and ADM and pulmonary pressure was analysed in the hyperthyroidism patients with pulmonary hypertension. [Results] The results showed that the plasma levels of U Ⅱ and ADM were significeantty higher in the hyperthyroidism patients with pulmonary hypertension than in those without pulmonary hypertension （all P 〈0.01）.A positive correlation was found between plasma level of UⅡand pulmonary pressure （r =0.496, P 〈0.01）, between plasma level of ADM and pulmonary pressure （r =0.483, P 〈0.01） in the hyperthyroidism patients with pulmonary hypertension. [ Conclusion] The high plasma concentrations of U II and ADM might play an important role in the pathological process of pulmonary hyperten- sion development in the hyperthyroidism patients with pulmonary hypertension.

关 键 词：甲状腺功能亢进症 肺动脉高压 尾加压素Ⅱ 肾上腺髓质素 

分 类 号：R581.1[医药卫生—内分泌]