交感神经对小鼠妊娠早期血清中性激素的影响  

Effects of sympathetic nerve on serum sex steroids of mice during early embryonic development

作　　者：张玉仙[1] 董玉兰[2] 陈耀星[2] 王子旭[2] 白永平[2] 谢电[2] 赵娇慧[2] 

机构地区：[1]北京农业职业学院,北京房山102442 [2]中国农业大学动物医学院,北京海淀100193

出　　处：《中国兽医杂志》2009年第8期6-8,共3页Chinese Journal of Veterinary Medicine

基　　金：国家自然科学基金资助(39500108;30270960;30700575);教育部博士点基金(200800191004)

摘　　要：本文运用交感神经阻断剂6-OHDA(100 mg/kg体重)腹腔注射昆明系小鼠,研究交感神经对妊娠早期外周血清性激素水平的影响。结果显示:交感神经损毁后,妊娠早期外周血清中雌二醇浓度着床前(E3)升高明显,着床期下降;血清中孕酮浓度着床前升高,着床后降低。结论:交感神经通过调控妊娠早期外周血性激素的生理水平,从而维持妊娠的发生,促进妊娠早期胚胎发育。The present study set up a proper animal model by intraperitoneal injection with 6-OHDA （100 mg/kg body weight）, which can damage the sympathetic nerve in order to explore the effects of sympathetic nerve system on sex steroid hormone in serum during early pregnancy. The results demonstrated that after destruction of the sympathetic nerves, the serum concentrations of 17 β-estradiol significantly increased at preimplantation （E3）, but decreased at implantation （ES）. At the same time, the serum concentrations of progesterone significantly increased during E1-ES, but then decreased during E7-E9. In conclusion, the sympathetic nerves played a role in modulating the levels of serum sex steroids during early pregnancy to maintain pregnancy and development of early enbryos.

关 键 词：交感神经 妊娠早期 性激素 小鼠 

分 类 号：S852.2[农业科学—基础兽医学]