维库溴铵残余肌松作用对成年全麻患者术后恢复的影响  

Effect of Residual Muscle Relaxant Effect of Vecuronium Bromide on Postoperative Recovery of Adult Patients with General Anesthesia

作　　者：陈猛[1] 温立勇[1] 李颖[1] 张鑫[1] 刘洋[1] 

机构地区：[1]牡丹江医学院红旗医院麻醉科,牡丹江市157011

出　　处：《中国医院用药评价与分析》2009年第8期611-612,共2页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨维库溴铵术后残余肌松作用持续时间,找出其安全应用的措施。方法:选择年龄>18岁、<45岁,无肝肾功能不全,手术时间短于2小时的全身麻醉志愿者60人,随机分为两组,每组记录术中及术后各时段TOF数据,其中第2组术后以新斯的明拮抗肌松残余作用,第1组不使用拮抗。结果:两组患者按传统拔管指征拔除气管导管后均存在肌松残余作用,第2组作用时间明显短于第1组。结论:维库溴铵在按传统拔管指征拔除气管导管后存在肌松残余作用,且此作用时间较长,故应慎重对待。OBJECTIVE：To investigate the postoperative duration of residual muscle relaxant effect of vecuronium bromide and to explore the measures for its safe use.METHODS：60 volunteers（aged 〉18 and 〈45）undergoing general anaesthesia without impairment in liver and kidney within 2 hours of operation time were randomly divided into two groups.The TOF data at each time stage during and after operation were recorded.After operation,Group II received neostigmine to antagonize residual muscle relaxant effect whereas Group I received no antagonist.RESULTS：Residual muscle relaxant effect was noted in both groups after withdrawal of tracheal catheter in accordance with traditional indications for extubation,and the action time in neostigmine-treated group（Group II）was significantly shorter than in Group 1.CONCLUSION：Vecuronium bromide has long-lasting residual muscle relaxant effect in patients after withdrawal of tracheal catheter in accordance with traditional indications for extubation,which should be treated with caution.

关 键 词：维库溴铵 七氟烷 肌肉松驰药 残余作用 

分 类 号：R971.2[医药卫生—药品]