HLA-A和HLA-B的多态性与先兆子痫(英文)  

Polymorphism of HLA-A and HLA-B in pre-eclampsia

作　　者：张展[1] 贾莉婷[1] 张琳琳[1] 

机构地区：[1]郑州大学附属第三医院检验科,郑州450052

出　　处：《北京大学学报（医学版）》2009年第4期418-425,共8页Journal of Peking University:Health Sciences

基　　金：Supported by National Natural Science Foundation of China (30872316)~~

摘　　要：Objective:To investigate the association between the polymorphism of HLA-A,HLA-B genes and pre-eclampsia. Methods:HLA-A,HLA-B genotyping was performed by polymerase chain reaction sequence-specific primer (PCR-SSP) in 119 preeclampsia patients,117 normal pregnant women and their neonates. Results:The study showed that 16 HLA-A and 39 HLA-B alleles were obtained in pre-eclamptic patients and normal pregnant women. 15 HLA-A and 37 HLA-B alleles were obtained in their neonates. No significant difference was found in maternal or neonatal HLA-A,HLA-B alleles between pre-eclampsia group and control group (Pc>0.05). The frequencies of HLA-A11,HLA-A24,HLA-B13,HLA-B14,HLA-B15,HLA-B52 maternal/fetus genetic assoications were significantly diffe-rent between pre-eclampsia group and control group (P<0.05). Conclusion:Some HLA-A,HLA-B maternal/fetus special bindings may be associated with the susceptibility or protective of pre-eclampsia.Objective：To investigate the association between the polymorphism of HLA-A,HLA-B genes and pre-eclampsia. Methods：HLA-A,HLA-B genotyping was performed by polymerase chain reaction sequence-specific primer （PCR-SSP） in 119 preeclampsia patients,117 normal pregnant women and their neonates. Results：The study showed that 16 HLA-A and 39 HLA-B alleles were obtained in pre-eclamptic patients and normal pregnant women. 15 HLA-A and 37 HLA-B alleles were obtained in their neonates. No significant difference was found in maternal or neonatal HLA-A,HLA-B alleles between pre-eclampsia group and control group （Pc〉0.05）. The frequencies of HLA-A11,HLA-A24,HLA-B13,HLA-B14,HLA-B15,HLA-B52 maternal/fetus genetic assoications were significantly diffe-rent between pre-eclampsia group and control group （P〈0.05）. Conclusion：Some HLA-A,HLA-B maternal/fetus special bindings may be associated with the susceptibility or protective of pre-eclampsia.

关 键 词：HLA—A抗原 HLA—B抗原 先兆子痫 多态现象 遗传 等位基因 

分 类 号：R714.244[医药卫生—妇产科学]