神经干细胞移植治疗遗传性小脑萎缩的临床研究(英文)  

Clinical study of transplantation of neural stem cells in therapy of inherited cerebellar atrophy

作　　者：田增民[1] 陈涛[1] Nanbert ZHONG 李志超[1] 尹丰[1] 刘爽[1] 

机构地区：[1]海军总医院全军神经外科中心,北京100048 [2]北京大学基础医学院医学遗传学系

出　　处：《北京大学学报（医学版）》2009年第4期456-458,共3页Journal of Peking University:Health Sciences

摘　　要：Objective:To study the clinical effect of neural stem cell transplantation in the treatment of inherited cerebellar atrophy (CA). Methods:The cells from human fetal cerebellum (8-10 weeks of gestation) were grown and expanded in vitro. The cultured neurospheres were then implanted into the dentate nuclei of patients by stereo tactic operation. Totally,12 patients (7 males and 5 females with age ranging 22-62 years,mean 43 years) were treated by this operation from August 2006 to August 2008. Results:The cells of fetal cerebellum were expanded by 107 folds in undifferentiated state in the culture. After the operation,no rejection was detected. Follow up,the effective rates were 58.3% after 3 months,75.0% after 6 months,and 66.7% for 12-24 months (mean 18 months). Conclusion:the transplantation of in vitro cultured neural stem cell is a feasible and effective treatment for inherited CA,but the long term effectiveness need to be taken in consideration.Objective：To study the clinical effect of neural stem cell transplantation in the treatment of inherited cerebellar atrophy （CA）. Methods：The cells from human fetal cerebellum （8-10 weeks of gestation） were grown and expanded in vitro. The cultured neurospheres were then implanted into the dentate nuclei of patients by stereo tactic operation. Totally,12 patients （7 males and 5 females with age ranging 22-62 years,mean 43 years） were treated by this operation from August 2006 to August 2008. Results：The cells of fetal cerebellum were expanded by 107 folds in undifferentiated state in the culture. After the operation,no rejection was detected. Follow up,the effective rates were 58.3% after 3 months,75.0% after 6 months,and 66.7% for 12-24 months （mean 18 months）. Conclusion：the transplantation of in vitro cultured neural stem cell is a feasible and effective treatment for inherited CA,but the long term effectiveness need to be taken in consideration.

关 键 词：橄榄体桥脑小脑萎缩 干细胞移植 治疗结果 

分 类 号：R617[医药卫生—外科学]