2型糖尿病口服耐药者血清GAD抗体的检测及意义  

DETECTION OF GLYTAMATE DECARBOXYLASE ANTIBODY IN SERUM OF ORALLY DRUG RESISTANCE PATIENTS WITH TYPE 2 DIABETES AND ITS SIGNIFICANE

作　　者：张晓莉[1] 张红军[1] 王妍[1] 

机构地区：[1]牡丹江医学院,黑龙江牡丹江157011

出　　处：《牡丹江医学院学报》2009年第4期4-5,共2页Journal of Mudanjiang Medical University

基　　金：黑龙江省教育厅基金资助(10511145);牡丹江医学院基金资助重点项目(2001002)

摘　　要：目的:探讨2型糖尿病口服耐药现象与血清谷氨酸脱羧酶抗体(GADA)产生的相关性。方法:将72例2型糖尿病患者根据降糖药治疗效果分成口服耐药组和口服药有效组,检测两组患者血中GADA,血糖及餐后空腹和C肽水平。结果:C肽水平口服耐药组明显低于口服药有效组(p<0.005),血糖水平口服耐药组明显高于口服药有效组(p<0.001),口服耐药组GADA检出率明显高于口服药有效组(p<0.05)。结论:GADA在2型糖尿病口服耐药人群检出率较高,提示2型糖尿病人口服降糖药耐药现象可能与胰岛β细胞功能的免疫损伤有关。Objective：To investigate the relation of orally drug resistance patients with type 2 diabetes and serum glutamate deearboxylase antibody （GADA）. Methods：72 type 2 diabetes patients were randomly grouped in orally drug resistance group and orally drug utility group, then we detected GADA, fasting and postprandial blood sugar and peptide C of the patients. Results：The level of peptide C of orally drug resistance group is lower than that of orally drug utility group（ p 〈 0. 005 ）. The blood sugar level of orally drug resistance group is higher than that of orally drug utility group（ p 〈 0.001 ）. GADA - detected rate in orally drug resistance group is obviously higher than that of orally drug utility group （ p 〈 0.05 ）. Conclusion： GADA - detected rate in orally drug resistance group is obviously higher hint that orally drug resistance in type 2 diabetes maybe relate to immune impairment of beta cell of islet.

关 键 词：2型糖尿病 谷氨酸脱羧酶抗体 口服耐药 

分 类 号：R58[医药卫生—内分泌]