HIV感染者44例血清小分子多肽抗体检测分析  

Serum Anti-R7V Antibody Detection:Clinical Analysis of Features of 44 Chinese HIV Carriers

作　　者：吴焱[1] 伦文辉[1] 李兴旺[1] 张四平[1] 刘亚楠[1] 

机构地区：[1]北京地坛医院性病艾滋病中心,北京市100015

出　　处：《中国全科医学》2009年第18期1675-1676,1680,共3页Chinese General Practice

基　　金：北京市科技计划课题(D0906003040291)

摘　　要：目的通过检测HIV感染者血清小分子多肽抗体(抗-R7V)并分析相关临床资料,初步探讨中国HIV感染者体内抗-R7V的阳性情况及其与临床特征之间的关系。方法对44例HIV感染者进行详细的病史和流行病学调查,使用ELISA试剂盒检测抗-R7V,同时进行CD4+T细胞、病毒载量、血脂(胆固醇和三酰甘油)和乙肝五项的检测。结果44例HIV感染者中抗-R7V阳性9例,灰区6例,阴性29例。抗-R7V阳性率在不同性别和不同感染方式的HIV感染者中差别无统计学意义。在感染时间>10年者抗-R7V阳性率为25.9%(7/27),而在≤10年者抗-R7V阳性率为11.8%(2/17),二者间差别无统计学意义(χ2=1.29,P=0.26)。CD4+T细胞数在抗-R7V阳性者〔(449±102)×106/L〕和阴性患者〔(370±103)×106/L〕之间差别有统计学意义(P=0.044),病毒载量在抗-R7V阳性者和抗-R7V阴性者之间差别有统计学意义(P=0.031)。结论HIV感染者中血清抗-R7V阳性率为20.5%,CD+T细胞计数较高、病毒载量较低的感染者抗-R7V阳性率较高。Objective To probe initially into the relationship of anti - R7V positive to clinical features in Chinese HIV carriers, detecting serum anti - R7V antibody and analyzing related clinical data. Methods Investigation was performed on detailed case histories and on epidemiology in 44 Chinese HIV carriers. Anti - R7V was detected using ELISA kit, and CD4^＋T cell, viral load, blood lipids （cholesterol and triglycerides ） and hepatitis B were also detected at the same time. Results Of 44 HIV carriers, anti - R7V positive was noted in 9, negative in 29, gray zone in 6. There was not significant difference in anti - R7V positive rate between different genders and forms of infection. Anti - R7V positive rate of carriers infected over 10 years was 25.93% （7/27）, and that of carriers infected for 10 years or fewer was 11.76% （2/17）, the difference was not significant （ Х^2 = 1.29, P =0.26）. There was significant difference in CD4^＋ T cell count between anti - R7V positive carriers （449 ±102/mm^3） and negative （370 ±103/mm^3） （P=0.044）, and difference was found in viral load （P=0.031）. Conclusion Positive rate of anti - R7V antibody in Chinese HIV carriers is 20. 45%. The positive rate is higher in patients infected more than 10 years, who have higher CDs count and lower viral load.

关 键 词：人类免疫缺陷病毒 抗-R7V 病毒载量 CD4 

分 类 号：R373.51[医药卫生—病原生物学]