冠心病病人血清IMA与sICAM-1变化及意义  

THE CHANGES AND CLINICAL SIGNIFICANCE OF ISCHEMIA MODIFIED ALBUMIN AND SOLUBLE INTERCELLULAR ADHESION MOLECULE-1 IN PATIENTS WITH CORONARY HEART DISEASE

作　　者：陈文一[1] 王红巧 张丰雪[3] 

机构地区：[1]青岛市妇女儿童医疗保健中心,山东青岛266011 [2]青岛市海慈医疗集团 [3]山东科技大学校医院检验科

出　　处：《青岛大学医学院学报》2009年第6期517-518,521,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨冠心病（CHD）与血清缺血修饰清蛋白（IMA）和可溶性细胞间黏附分子-1（sICAM-1）浓度变化的关系。方法采用酶联免疫吸附测定法检测120例CHD病人血清IMA和sICAM-1浓度的变化，并与40例对照者进行比较。结果CHD病人血清IMA与sICAM-1水平显著高于对照组（t’=18．45、11．02，P〈0．001）。急性心肌梗死、不稳定型心绞痛及稳定型心绞痛病人IMA和sICAM-1水平比较，差异有显著性（F=102．16、32．81，q=3．70～20．24，P〈0．001）。不同类型CHD病人血清IMA与sICAM-1水平均呈显著正相关（r=0．609-0．855，P〈0．01）。结论血清IMA和sICAM-1浓度变化参与CHD的发生与发展，且与病情严重程度有关。Objective To explore the association of the changes of serum ischemia modified albumin （IMA） and soluble intercellular adhesion molecule-1 （sICAM-1） levels with coronary heart disease （CHD）. Methods The concentrations of serum IMA and sICAM-1 in 120 CHD patients were determined by ELISA and compared with 40 controls. Results The serum IMA and sICAM-1 in the CHD were higher than those in the controls （t＇=18.45,11.02;P〈0. 001）. The differences of serum levels of IMA and sICAM-1 among the AMI, UAP and SAP patients were significant （F= 102. 16,32.81;q=3.70- 20.24;P〈0. 001）. There was a positive correlation between IMA and sICAM-1 in patients with different type CHD （r= 0. 609-0. 855, P〈0.01）. Conclusion The changes of serum IMA and sICAM-1 involve in the onset and development of CHD,which is associated with the severity of the disease.

关 键 词：冠状动脉疾病 细胞黏附分子 缺血修饰清蛋白 

分 类 号：R541.41[医药卫生—心血管疾病]