抗Sm抗体阳性系统性红斑狼疮临床特征学研究  

STUDY ON THE CLINICAL FEATURES OF SYSTEMIC LUPUS ERYTHEMATOSUS WITH POSITIVE ANTI-Sm ANTIBODY

作　　者：李洋[1] 臧运书[1] 刘芝军[2] 吴梅 

机构地区：[1]青岛大学医学院附属医院皮肤科,山东青岛266003 [2]青岛大学医学院附属医院小儿注射科 [3]山东省皮肤性病防治研究所

出　　处：《青岛大学医学院学报》2009年第6期567-568,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的了解抗Sm抗体阳性系统性红斑狼疮（SLE）病人的临床特征。方法对42例抗Sm抗体阳性的SLE门诊病人临床资料进行分析，并与40例抗Sm抗体阴性SLE病人的临床资料进行比较。结果抗Sm抗体阳性的SLE病人病程较短，光敏感、关节痛、白细胞减少、蛋白尿下降、补体C3下降的发生率均高于对照组（t=7．38，Х^2=3．60～10．98，P〈0．05、0．01）。结论抗Sm抗体阳性SLE病人的临床表现明显，更易于做出早期诊断。抗Sm抗体阳性病人更易早期出现肾脏损害，提示预后不良。Objective To comprehend the clinical features of positive anti-Sin antibody （ASA） patients with systemic lupus erythematosus （SLE）. Methods Clinical data of 42 SLE patients with positive ASA were analyzed and compared with 42 SLE ones with negative ASA. Results The course of SLE patients with positive antibody was shorter than that of those with negative antibody, and more photaesthesia, arthralgia, leucopenia, decrease of proteinuria and complement C3 （t =7. 38;Х^2= 3.60-10.98;P〈0.05,0.01）. Conclusion The clinical manifestations of anti-Sin positive SLE patients are more obvious and early diagnosis is easier to be made, the prognosis is poor because of early damage of the kidney.

关 键 词：红斑狼疮 系统性 抗SM抗体 疾病特征 

分 类 号：R593.241[医药卫生—内科学]