凝血酶-抗凝血酶复合物等在慢性阻塞性肺疾病急性加重期的应用  

APPLICATION OF THROMBIN-ANTITHROMBIN COMPLEX IN TREATMENT OF PATIENTS WITH ACUTE AND ANXIETY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

作　　者：高志国[1] 

机构地区：[1]邢台市人民医院呼吸科,邢台054001

出　　处：《现代预防医学》2009年第15期2972-2973,共2页Modern Preventive Medicine

摘　　要：[目的]通过检测慢性阻塞性肺疾病急性加重期患者中的D-二聚体,凝血酶-抗凝血酶复合物,纤溶酶-抗纤溶酶复合物,蛋白C的表达情况和临床意义,探讨其在慢性阻塞性肺疾病急性加重期的诊断的临床意义,并为慢性阻塞性肺疾病急性加重期治疗过程提供血清学依据。[方法]实验组选取105例符合慢性阻塞性肺疾病急性加重期诊断标准患者(对照组选取慢性阻塞性肺疾病急性缓解期),分别采静脉血,进行凝血酶原时间,凝血酶时间,部分凝血活酶时间,血小板计数,D-D,TAT,PAP,D-D,PC8项血清指标的定量测定。[结果]慢性阻塞性肺疾病急性加重期的患者血浆中D-D,TAT,PAP,PC的含量与对照组中的D-D,TAT,PAP进行比较,差异有统计学意义(P﹤0.01)。[结论]D-D,TAT,PAP。To investigate the expression situation and clinic significance of D-Dimer （DD）, Thrombin-Antithrombin Complex （TAT）, lasmin-Antiplasmin Complex （PAP） and Protein C （PC） in AECOPD, and discuss the significance of them in detection of AECOPD as well as offer the serologic basis in treatment of AECOPD. [Methods] 105 patients of AECOPD were selected as experiment group and patients with acute paracmasia COPD were selected as control group. The venous blood of everyone in both groups were sampled to perform quantitative determination of plasma prothrombin time （PT）, prothrombin time （TT）, kadin partial thromboplastin time （APTT）, the amount of blood platelet, DD, TAT, PAP and PC. [Results] Serum concentrations of D-D, TAT, PAP were significantly higher in patients in AECOPD group than in control group （P﹤0.01）. Serum concentration of PC was significantly lower in patients in COPD group than in control group （P ﹤0.01）. [Conclusion] The concentrations of DD, TAT, PAP and PC significant change in patients of AECOPD.

关 键 词：肺疾病 慢性阻塞性 D-二聚体 凝血酶-抗凝血酶复合物 纤溶酶-抗纤溶酶复合物 蛋白C 

分 类 号：R563.1[医药卫生—呼吸系统]