雌激素对更年期女性冠心病的影响  

Effects of Estrogen on Coronary Heart Disease in Menopausal Women

作　　者：苏雪梅[1] 姜国攀[1] 唐慧[1] 闫弘睿[1] 任峰[1] 关林[1] 

机构地区：[1]吉林省人民医院心内科,长春市130021

出　　处：《中华全科医学》2009年第10期1037-1039,共3页Chinese Journal of General Practice

摘　　要：目的探讨小剂量组织选择性雌激素活性调节剂对更年期女性冠心病的影响。方法入选对象经筛选分为非冠心病组及冠心病组,组内再分为观察组及对照组,观察组给予小剂量雌激素,观察其对更年期女性冠心病的影响。结果观察组治疗后与治疗前血液学相关指标有明显变化(P<0.05,或P<0.01),治疗后E2水平与对照组比较明显升高(P<0.01);非冠心病组治疗后冠心病发生率明显降低(P<0.05),而冠心病组观察组与对照组差异无统计学意义(P>0.05);更年期症状明显改善。结论小剂量组织选择性雌激素早期应用可延缓动脉粥样硬化,有益于冠心病一级预防,并有效改善更年期症状,但对冠心病二级预防获益不大。Objective To investigate the effects of low-dose selective estrogen activity regulator on the coronary heart disease （CHD） in menopausal women. Methods The selected individuals were divided into groups of non-CHD and CHD group, each group was further divided into observation group and control group. The low-dose of estrogen was administrated to the observer group, and the effects of the low-dose estrogen on coronary heart disease in menopausal women were observed. Results After the treatment,the related indexes on hematology had obvious changes in observation group （P 〈 0.05 or P 〈 0.01 ）, E2 level increased significantly as compared with controls（ P 〈 0.01 ） ;in non-CHD group, the treatment significantly reduced the incidence of CHD（ P 〈 0.05 ）. There was no significant difference between the observation group and the control group of CHD group（ P 〉 0.05 ）. The climacteric symptoms were improved significantly. Conclusion The early use of low-dose selective estrogen can delay atherosclerosis and can improve menopausal symptom effectively, is beneficial in primary prevention of CHD, but not to sec- ondary prevention of coronary disease.

关 键 词：雌激素 更年期女性 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病] R711.75[医药卫生—内科学]