布拉酵母菌预防小儿抗生素相关性腹泻的临床研究  

Effect of Saccharomyces boulardii on prevention of antibiotic-associated diarrhea： a prospective randomized placebo-controlled trial

作　　者：吉大章[1] 邹商群[1] 熊琴[1] 袁梁玉[1] 雷辉[1] 梁盈盈[1] 

机构地区：[1]广东省珠海市妇幼保健院儿科,519001

出　　处：《中国医药》2009年第10期818-819,共2页China Medicine

摘　　要：目的探讨布拉酵母菌对小儿支气管炎和肺炎抗生素相关性腹泻（AAD）的预防作用。方法195例患有支气管炎和肺炎住院儿童完全随机分成2组，治疗组95例，自开始使用抗生素起口服布拉酵母菌散剂250mg／次，2次／d；对照组100例，仅使用抗生素，出现腹泻后2组患儿均加用蒙脱石散剂和补液治疗。比较2组患儿的抗生素相关性腹泻率。结果治疗组8例（8．4％）患儿发生AAD，对照组25例（25．0％）患儿发生AAD，2组患儿AAD发生率差异有统计学意义（r=9．52，P〈0．05）。治疗组AAD患儿腹泻持续时间（3．0±1．8）d，较对照组（5．0±2．0）d短，差异有统计学意义（t=7．4，P〈0．05）。治疗组中，≤3岁儿童AAD发生率比〉3岁儿童高，差异无统计学意义（P〉0．05）。对照组中，≤3岁儿童AAD发生率比〉3岁儿童明显升高，差异有统计学意义（P〈0．05）。结论布拉酵母菌能有效预防小儿抗生素相关性腹泻。Objective To assess the preventive efficacy of Saccharomyces boulardii for children with bronchitis and pneumonia on antibiotic-associated diarrhea. Methods One hundred and ninety-five hospitalized children diagnosed with bronchitis or pneumonia were included in a randomized parallel placebo-controlled trial. Children received standard antibiotics and S. boulardii for 7-10 days. The placebo group received standard antibiotics only. The incidence of antibiotic-associated diarrhea was compared in two groups. Results Of the 195 eligible patients, children receiving Saccharomyces boulardii developed significantly less AAD （ with incidence of 8.4% ） compared with 25.0% in placebo group （ P 〈 0.05 ）. The diarrhea duration in treatment group was significantly shorter than that in placebo group （ P 〈 0.05 ）. Conclusion The prophylactic use of Saccharomyces boulardii together with antibiotics resulted in a significant reduction of AAD with no serious adverse reactions and shortened duration of diarrhea.

关 键 词：抗生素相关性腹泻 布拉酵母菌 微生态制剂 

分 类 号：R725.7[医药卫生—儿科]