慢性阻塞性肺疾病急性加重期痰热证模型大鼠血浆内皮素、降钙素基因相关肽的变化及通塞颗粒的作用  

The Change of Calcitonin Gene-Related Peptide and Plasma Endothelin in Rat's Model of Sputum-Pyretic Syndrome in Chronic Obstructive Pulmonary Diseases Acute Exacerbation and Action of Tongsai Granula

作　　者：周红艳[1] 乔翠霞[2] 张艳霞[2] 李建生[2] 

机构地区：[1]河南省中医药研究院,河南郑州450004 [2]河南中医学院老年医学研究所,河南郑州450008

出　　处：《河南中医学院学报》2009年第5期25-26,共2页Journal of Henan University of Chinese Medicine

基　　金：国家自然科学基金(编号:30772797);河南省高校新世纪优秀人才支持计划(编号:2006HANCET-05)

摘　　要：目的:探讨慢性阻塞性肺疾病急性加重期(AECOPD)痰热证模型大鼠血浆内皮素(ET)及降钙素基因相关肽(CGRP)的变化及通塞颗粒的作用。方法:通过烟熏、滴菌结合风热刺激的方法建立AECOPD痰热证大鼠模型。采用非平衡法测定血浆ET、CGRP含量。结果:模型组较正常组ET升高(P<0.01),CGRP下降(P<0.05);通塞颗粒组ET较模型组降低(P<0.05),CGRP升高(P<0.05)。结论:ET、CGRP参与了AECOPD的病理生理过程,调节血浆中ET、CGRP的水平可能是通塞颗粒治疗COPD的作用机制之一。Objective： To approach the change of CGRP and plasma ET in rat＇ s model of sputum - pyretic syndrome in chronic obstructive pulmonary diseases acute exacerbation and action of Tongsai granula. Methods ： By smoking and bead bacterium and united wind heat stimulation to setup rat＇ s model of phlegm and pyretic syndrome of AECOPD. Assay content of plasma ET and CGRP with imbalance method. Results： ET in model team is higher than in common team（ P 〈 0.01 ） ,CGRP in model team is lower（ P 〈0.05 ）, ET in Tongsai granula team is lower than model team （ P 〈 0.05 ）, CGRP is higher （ P 〈 0.05 ）. Conclusion ： ET and CGRP participated the pathophysiology processes of AECOPD, one of the mechanism of action of Tongsai granula to treat COPD is adjusting level of plasma ET and CGRP.

关 键 词：慢性阻塞性肺疾病 急性加重期 痰热证 血浆内皮素 降钙素基因相关肽 通塞颗粒 

分 类 号：R285.5[医药卫生—中药学]