一氧化氮参与艾灸对大鼠急性胃粘膜损伤的保护作用  

Nitric Oxide Participates in the Protection of Moxibustion on Acute Gastric Mucosal Damage in Rats

作　　者：王月芳[1] 刘元亮 陈华德[1] 许冠荪[2] 孙勇[2] 裴文芬 朱舜丽[2] 陈全珠[2] 

机构地区：[1]浙江中医学院针灸推拿系,杭州310009 [2]安徽中医学院针灸经络研究所,合肥230038

出　　处：《针刺研究》1998年第2期140-145,共6页Acupuncture Research

摘　　要：本实验用70％酒精胃内注射建立大鼠急性胃粘膜损伤模型，研究了艾灸足三里对胃粘膜保护作用的可能机理。结果发现：与对照组相比，艾炙组大鼠胃粘膜血流量、跨膜电位差、血清及胃窦、胃体中一氧化氛含量均升高（P＜0．05），粘膜损伤指数下降（P＜0．05）；NW-硝基-L-精氨酸（L-NNA）能阻断上述效应（P＜0．05）；用左旋精氨酸（L－Arginine）或硝普钠（Snap）预处理，均能明显减轻大鼠胃粘膜损伤（P＜0．05）。提示NO参与艾灸对冒粘膜的保护作用。:The experiment, in which model of gastric mucosal damage was induced by 70 % ethanol (IG),and its GMBF, PD LI, NO level of serum, antrum, and corpus were explored, is to study the protec tive effect of moxibustion on acute gastric mucosal damage in rats and its mechanism. The results indi cated that GMBF, PD of moxibustion group were significantly increased compared with model group,LI was decreased (P<0. 05) and pretreatment with L-NNA could aggravate gastric mucosal damage,while this effect was reversed by concurren administration of L-arginine. Pretreatment with snap or Larginine both also significantly attenuated gastric mucosal damage (P<0.05 or P<0.01). Those told that moxibustion can promote the protective effect of gastric mucosal, prevent gastric mucosal damage, and the NO participates in the mechanism of moxibustion

关 键 词：艾灸 胃粘膜损伤 一氧化氮 

分 类 号：R245.81[医药卫生—针灸推拿学] R259.73[医药卫生—中医临床基础]