直流电针治疗大鼠实验性恶性肿瘤的疗效观察  

The Curative Effect of Direct Current Electrical Needle on Experimental Malignant Tumor

作　　者：李朝晖[1] 王佩[1] 赵连珠[1] 高凤鸣[2] 董金蝉[2] 森和 

机构地区：[1]北京针灸骨伤学院实验针灸教研室,北京100015 [2]卫生部工业卫生实验所 [3]日本明治针灸大学东洋医学教室

出　　处：《针刺研究》1998年第2期149-152,共4页Acupuncture Research

摘　　要：本实验采用ZAY-6B*型直流电针仪（北京航空航天大学研制）治疗大鼠实验性恶性肿瘤，取得良好疗效。肿瘤模型：用Walker256病株（中国医学科学院药物所提供）接种Wistar大鼠48只，治疗组23只，对照组25只。治疗方法：瘤株接种约一周后，瘤体直径达1cm左右时，采用三极电针法（一阳二阴）进行治疗。电压5～7V，治疗电量为100C／cm（肿瘤直径）。实验结果：①治疗组存活时间明显延长，平均存活40天以上，对照组平均存活14．5天（P＜0．05），有明显差异。10天上生存率，治疗组为78．3％，对照组72％；20天以上生存率，治疗组为52．2％；对照组20％；30天以上生存率，治疗组为30．4％，对照组0％；80天以上生存率，治疗组为30．4％，对照组0％。②瘤体比较。治疗组经电针后，瘤体变软变黑，坏死吸收，形成疤痕，对照组肿瘤持续生长，直至死亡，死亡时的平均瘤重为15．88g。疗效机理：直流电场使局部肿瘤组织产生强电解作用，肿瘤细胞内环境的酸碱度发生严重改变，阳极区pH值降至2，阴极区pH值升至12，破坏了肿瘤细胞生长的条件，使细胞变性坏死。本实验的观察结果表明，直流电针治疗实验性恶性肿瘤疗效肯定。该方法操作简便，安全有效，对局部组织损伤较小，于机体未见毒、副作用。The curaive effect of direct current (DC) electrical needle on malignant tumor was observed.Forty-eight Wistar rats inoculaed with Walker-256 tumor line under right axillare skin were divided into two groups. There were 23 rats in test group and 25 in conrol group. After a week, the diameter of tumor reached 1cm. The rats (23) in test group were treated by DC electrical needle with 5~7V,10~20mA and 100C, while the rats (25) in control group were not taken any treament.Results:①The average survival days (>38 days)of test group were significantly longer than that of control group (14. 5). The average survival rates of 20 to 70 days were also significantly different.②Tumor body: The tumor of test group became necrosis after treatment. It was absorbed and was re placed by scar at last. The tumor of control group enlarged continually until the rats died. ③ Mecha nism: The DC electrical needling could make tumor tissue electrolysis. During the treatment, the seri ously changed pH was the key role that killed tumor ce1ls. The pH value around POsitive pole decreased to 2 while that around negative pole increased to 12. The tumor ce1ls degenerated to necrosis gradully due to the changes of internal environment. These results demonstrate that DC electrical needling is both effective and safe for experimental malignant tumor therapy. Its mechanisms need to be further researched

关 键 词：肿瘤 直流电针 酸碱度 疗效 

分 类 号：R246.5[医药卫生—针灸推拿学] R245.97[医药卫生—中医临床基础]