异丙酚消除快速起搏预适应对离体缺血心肌的保护作用  

Propofol eliminates the protective effect of heart pacing-induced preconditioning on the isolated ischemic myocardium

作　　者：毛卫克[1] 袁世荧[1] 姚尚龙[1] 

机构地区：[1]同济医科大学附属协和医院麻醉科,武汉市430022

出　　处：《中华麻醉学杂志》1998年第8期482-485,共4页Chinese Journal of Anesthesiology

摘　　要：目的:研究异丙酚对快速起搏预适应的缺血心肌保护效应的影响。方法:24只白兔随机分成缺血对照,起搏缺血和异丙酚+起搏缺血组。结果:起搏组全心缺血30分钟再灌30分钟时左室收缩功能(LVDP、+dp/dt_(max))及舒张功能(-dp/dt_(max))的恢复明显优于缺血对照组(P<0.05),起搏期间给予异丙酚10μmol/L,使缺血后LV+dp/dt_(max),LVDP和LVEDP的恢复幅度显著差于起搏缺血组(P<0.05),且再灌注30分钟末LDH,CPK活性和ADP含量明显高于起搏缺血组,ATP含量则低于上述组。结论:异丙酚可缓解快速起搏即刻的心肌挛缩,但却消除其对缺血心肌的预适应效应。To study the effect of propofol on the protection of ischemic isolated heart preconditioned by rapid heart pacing. Method: 24 white rabbits were assigned randomly into ischemia control (IC), pacing+ischemia (PI), and propofol+pacing+ischemia (PPI)group. Result: After 30 min of total heart isehemia followed by 30 min reperfusion, the recovery level of LVDP, LV+dp/dt max and LV-dp/dt max is much better in PI group than that of IC group (P<0.05). After propofol 10μmol was perfused during quick pacing period before ischemia, the recovery level of LVDP, LV+dp/dt max and LVEDP during reperfusion was worse significantly than those of PI group (P<0.05), the higher levels of LDH, CPK activity(P<0.05)and ADP content(P<0.05), and'a lower level of ATP content(P<0.05)in myocardium at the end of reperfusion were observed in PPI group than those of PI group. Conclusion: Propofol eliminates the protective effect of heart pacing-induced preconditioning on myocardium inspite of attenuating the ischemic contracture induced by quick heart pacing.

关 键 词：异丙酚 预适应 心肌再灌注损伤 

分 类 号：R971.2[医药卫生—药品] R542.2[医药卫生—药学]