晶体表面结合蛋白对草酸钙晶体生长的抑制作用  

In vitro inhibition of calcium oxalate crystal growth by crystal surface binding proteins

作　　者：朱绍兴[1] 章咏裳[1] 刘继红[1] 李家贵[1] 

机构地区：[1]同济医科大学附属同济医院泌尿外科

出　　处：《中华泌尿外科杂志》1998年第8期457-459,共3页Chinese Journal of Urology

基　　金：国家教委资助

摘　　要：为观察晶体表面结合蛋白（ＣＳＢＰ）对草酸钙晶体生长的影响，用层析法分离提取正常人和草酸钙结石病人ＣＳＢＰ，应用种晶体技术检测ＣＳＢＰ、尿凝血酶原激活肽Ｆ１片段（ＵＰＴＦ１）和白蛋白在体外对草酸钙晶体生长的作用。结果发现正常人ＣＳＢＰ和ＵＰＴＦ１能显著抑制草酸钙晶体的生长，结石病人ＣＳＢＰ的抑制活性低于正常人。Crystal surface binding proteins(CSBP) were isolated by chromatography.The effects of proteins on calcium oxalate crystal growth in vitro were tested using a seeded crystallization technique.It was observed that CSBP and urinary prothrombin F1(UPTF1) of normal subjects could apparently inhibit calcium oxalate crystal growth.CSBP of stone formers showed lower inhibitory activity than that of normal.The inhibitory activity of albumin,whether in normal subjects or in stone formers,was weak.It was concluded that UPTF1 is a potent inhibitor of calcium oxalate crystal growth.A dificiency of UPTF1 in CSBP of stone formers may be related to calculogenesis.

关 键 词：尿结石 草酸钙 晶体表面 结合蛋白 晶体生长 

分 类 号：R691.402[医药卫生—泌尿科学]