原发性皮肤弥漫性大B细胞淋巴瘤,腿型  

Primary cutaneous diffuse large B-cell lymphoma,leg type:a case report

作　　者：蔓小红[1] 韩冰[1] 白彦萍[1] 姚志远[1] 

机构地区：[1]卫生部中日友好医院皮肤科,北京100029

出　　处：《临床皮肤科杂志》2009年第9期576-578,共3页Journal of Clinical Dermatology

摘　　要：报告1例原发性皮肤弥漫性大B细胞淋巴瘤,腿型。患者女,77岁。因右胫前多发暗红色斑块和结节3个月入院。皮损组织病理检查示:肿瘤细胞在真皮内弥漫性浸润性生长,侵及皮下组织,肿瘤细胞体积增大,形态不规则,细胞核大深染,核分裂象多见。免疫组化染色示:瘤细胞CD20(+),CD79a(+),Bcl-2(+),MuM-1(+)。诊断:原发性皮肤弥漫性大B细胞淋巴瘤,腿型。通过CD20单克隆抗体加CHOP化疗方案治疗,病情明显好转。A case of leg type primary cutaneous diffuse large B-cell lymphoma is reported. A 77-year-old woman presented with multiple dark-red plaques and nodules on the anterior shin of her right leg for 3 months. Histopathology of the skin specimens showed a dense diffuse neoplastic cell infiltration in the dermis and subcutaneous fat tissue. The neoplastic cells were large and irregular in shape, their nuclei were large, dark-stained and irregularly shaped. Mitotic figures were also observed. Immunohistochemistry study showed positive staining for CD20, CD79a, Bcl-2 and MuM-h She was diagnosed as primary cutaneous diffuse large B-cell lymphoma, leg type. Treated with anti-CD20 monoclonal antibody and CHOP chemotherapy, her condition was markedly improved.

关 键 词：淋巴瘤 大B细胞 弥漫性 皮肤 原发性 

分 类 号：R551.2[医药卫生—血液循环系统疾病]