黄芪多糖改善糖尿病仓鼠心肌糖脂代谢  

Astragalus polysaccharides improves glycolipid metabolism in myocardium of diabetic hamsters

作　　者：陈蔚[1] 陈雯洁[1] 夏燕萍[1] 叶红英[1] 俞茂华[1] 

机构地区：[1]复旦大学附属华山医院老年科,上海200040

出　　处：《中华内分泌代谢杂志》2009年第4期440-442,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：上海市科学委员会科研计划项目（05ZR14024）

摘　　要：探讨黄芪多糖对糖尿病仓鼠心肌糖脂代谢影响。观察糖尿病仓鼠血浆指标、脂肪和心肌病理、心肌超微结构、PPAR-α和葡萄糖转运蛋白（GLUT）4表达。黄芪多糖组糖脂代谢紊乱、心肌超微结构改善、PPAR—α和GLUT4的表达增高。黄芪多糖部分保护糖尿病心肌。The effect of astragalus polysaccharides （APS）on diabetic cardiomyopathy was investigated. The mRNA expressions of PPAR-α and GLUT4, pathology of adipose tissue and myocardium, and myocardial ultrastructure were studied. The pathological changes of adipose tissue and myocardium, as well as myocardial ultrastructure were well-improved; the gene expressions of PPAR-α and GLUT4 were raised in APS group. APS may be partially effective in treating diabetic cardiomyopathy.

关 键 词：黄芪多糖 糖尿病 PPAR-Α GLUT4 心肌病变 超微结构 

分 类 号：R686[医药卫生—骨科学]