脐血GH、IGF-Ⅰ、IGFBP-3水平与特发性胎儿生长受限的关系  

The Relationship between Growth Hormone,Insulin-like Growth Factor,Insulin-like Factor Binding Protein-3 in Cord Blood and Idiopathic Fetal Growth Restriction

作　　者：曹武军[1] 蒋晓敏[1] 陶芳标[2] 董娟[1] 朱鹏[2] 黄大雁[1] 

机构地区：[1]安徽省合肥市妇幼保健院,安徽合肥230001 [2]安徽医科大学公共卫生学院,安徽合肥230032

出　　处：《实用妇产科杂志》2009年第9期546-549,共4页Journal of Practical Obstetrics and Gynecology

基　　金：国家教育部博士点基金(编号:20060366002);安徽省高校省级自然科学研究项目(编号:KJ2008B294);合肥市科技局应用技术研究与开发项目(编号:2008-1007)

摘　　要：目的:探讨生长激素(GH)、胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、胰岛素样生长因子结合蛋白-3(IGFBP-3)与特发性胎儿生长受限(FGR)的关系。方法:采用巢式病例对照的研究设计方法,使用放射免疫分析法,检测42例FGR患者(特发性FGR组)和42例适于胎龄儿(正常对照组)脐血清中GH、IGF-Ⅰ、IGFBP-3水平,通过配对设计差值t检验、Pearson相关分析对实验结果进行统计分析。结果:①特发性FGR组GH水平高于正常对照组(P<0.01);特发性FGR组脐血IGF-Ⅰ、IGFBP-3水平均明显低于正常对照组(P<0.01);特发性FGR组脐血IGF-Ⅰ/IGFBP-3的比值低于正常对照组(P<0.01);②脐血GH水平与出生体重负相关(r=-0.443,P=0.000),脐血IGF-Ⅰ、IGFBP-3水平与出生体重正相关(r=0.497,P=0.000;r=0.331,P=0.000);脐血GH水平与IGF-Ⅰ水平负相关(r=-0.290,P=0.000),脐血IGF-Ⅰ水平与IGFBP-3水平正相关(r=0.245,P=0.024)。结论:GH、IGF-Ⅰ及IGFBP-3可能参与胎儿生长发育过程,是特发性胎儿生长受限发生的重要影响因素。Objective：To investigate the relations of growth hormone （GH）, insulin-likegrowth factor Ⅰ（IGF-Ⅰ）, and insulin-like growth factor binding protein（ IGFBP-3）with idiopathic fetal growth restriction. Methods： Blood samples were collected from umbilical cord in forty-two cases of fetal growth restriction infant with unclear etiologies （ FGR group） and forty-two cases of appropriate for gestational age infant （control group）by nested case-control study.The concentrations of GH, IGF- Ⅰ, and IGFBP-3 were measured by radioimmunoassay, and the results were analyzed and compared by paired samples t-test and correlation analysis.Results：The serum GH of umbilical cord in FGR group was significantly higher than control group （ P〈 0.0]） ; however, both serum IGF-Ⅰ and IGFBP-3 of umbilical cord were found in FGR group lower than in control group, same as the ratio of IGF-Ⅰ to IGFBP-3 （ P 〈 0.01）. The serum GH of umbilical cord was significantly negative correlation with birth weight （ r= - 0.443, P= 0.000） ; but IGF-Ⅰ and IGFBP-3 in umbilical cord was positively related with birth weight（ r= 0.497, P= 0.000; r= 0.33）, P= 0.000）. The serum GH of umbilical cord was significantly negative correlation with IGF-Ⅰ （ r= - 0.290, P= 0.000）, the serum IGFBP-3 of umbilical cord was significantly positive correlation with IGF- Ⅰ（ r= 0.24.5, P= 0.024）.Conclusions：GH, IGF-Ⅰ, and IGFBP-3 are involved in fetal intrauterine growth and play important role in the mechanism of idiopathic fetal growth restriction.

关 键 词：胎儿生长受限 小于胎龄儿 生长激素 胰岛素样生长因子-Ⅰ 胰岛素样生长因子结合蛋白质.3 

分 类 号：R714.51[医药卫生—妇产科学]