HIV-1 Nef下调MHC—Ⅰ分子研究进展  

Research progress about HIV-1 Nef downregulates mechanism to MHC- Ⅰ

作　　者：李杰[1] 吴南屏[1] 

机构地区：[1]浙江大学医学院附属第一医院传染病诊治国家重点实验室,杭州 310003

出　　处：《国际流行病学传染病学杂志》2009年第4期255-258,共4页International Journal of Epidemiology and Infectious Disease

基　　金：国家自然科学基金（30872241）

摘　　要：HIV-1感染机体后，HIV-1 Nef可以下调患者体内受染CD4^＋细胞表面MHC—Ⅰ分子，同时使受染细胞表面HIV-1抗原暴露水平降低，从而引起CILs识别该类受染细胞能力下降。这使得体内HIV-1躲避CTLs免疫应答和形成人体长期的慢性感染。Nef的这种功能与人体内HIV-1长期潜伏性有重要关系，对其深入研究可能为艾滋病治疗带来新的理论依据。此文就此进行相关综述。In HIV-1 infected patients, HIV-1 Nef can downregulate MHC- Ⅰ on the surface of the infected cells, and reduce the exposure levels of HIV-1 antigen on the surface of the infected cells simultaneously, so as to decrease the ability of cytotoxic T lymphocytes recognizing the infected cells. This effect of Nef may allow evasion of CTL lysis by HIV-1-infected cells and promote the formation of long-term chronic infection. There are important relations between the function of the Nef and HIV-1 long-term latent in patients. Deepening the research about the mechanism that HIV-1 Nef downregulates MHC-Ⅰ. can provide new theoretical basis for the treatment of HIV-1 diseases. Several areas mentioned above are reviewed in this article.

关 键 词：HW-1 调节机制 分子生物学 NEF MHC—Ⅰ AP-1 

分 类 号：R512.91[医药卫生—内科学] R446.42[医药卫生—临床医学]