半叶马尾藻化学成分的研究Ⅰ  

Chemical constituents of Sargassum hemiphyllum

作　　者：刘红兵[1,2] 崔征[1,2] 李玉山[1,2] 殷军 董焱[1,2] 丁文杰 刘彤[1,2] 陆保仁 

机构地区：[1]沈阳药科大学生药学教研室 [2]中国科学院海洋研究所

出　　处：《中国药学杂志》1998年第8期464-466,共3页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金

摘　　要：目的：对马尾藻科植物半叶马尾藻［Ｓａｒｇａｓｕｍｈｅｍｉｐｈｙｌｕｍ（Ｔｕｒｎ．）Ａｇ．］藻体的甾醇类成分进行研究。方法：利用真空液相层析、ＳｅｐｈａｄｅｘＬＨ２０层析和反复硅胶柱层析进行分离，根据甾醇的理化性质和光谱数据鉴定其结构。结果：得到５个甾醇类化合物，分别确定为岩藻甾醇（ＳＰⅠ）、２４氢过氧基２４乙烯基胆固醇（ＳＰⅡ），（２２Ｅ，２４Ｓ）２４甲基５α胆甾７，２２二烯３β，５，６β三醇（ＳＡⅢ），ｓａｒｉｎｇｏｓｔｅｒｏｌ（ＳＰⅣ）和麦角甾醇过氧化物（ｅｒｇｏｓｔｅｒｏｌｐｅｒｏｘｉｄｅ）（ＳＡⅥ）。结论：ＳＰⅡ。OBJECTIVE: To investigate the sterol constituents of the brown alga Sargassum hemiphyllum (Turn.) Ag. METHODS: Sterols were separated by VCL. Sephadex LH20 and rechromatography on slilca gel. Their structures were determined by spectral analysis and chemical evidence. RESULTS: Five marine sterols were isolated. They were elucidated as fucosterol (SPⅠ), 24hydroperoxy24vinylcholesterol (SPⅡ), saringosterol (SPⅣ), (22E, 24S)24methyl5αcholesta7, 22dien3β, 5, 6βtriol (SAⅢ) and ergosterol peroxide (SAⅥ). CONCLUSION: Compound SPⅡ, SAⅢ and SAⅥ were isolated from brown algae for the first time.

关 键 词：半叶马尾藻 海洋甾醇 甾醇过氧化物 化学成分 

分 类 号：R284.1[医药卫生—中药学] R282.77[医药卫生—中医学]