骨康宁冲剂治疗骨质疏松的药效学研究  

Pharmacodynamics of Gukangning Granular on osteoporosis

作　　者：岳南[1] 只德广[1] 赵益桂[1] 苏雅[1] 

机构地区：[1]天津药物研究院新药评价中心,天津300193

出　　处：《现代药物与临床》2009年第4期227-231,共5页Drugs & Clinic

摘　　要：目的观察骨康宁冲剂对骨质疏松的防治作用。方法采用维甲酸致大鼠骨质疏松模型、高分子右旋糖酐致大鼠高黏滞血症模型以及小鼠镇痛模型。结果与模型对照组比较,骨康宁明显升高骨质疏松大鼠的骨质量、骨密度、骨强度、TBV、血钙、骨灰质量、骨钙、骨磷,明显降低尿钙;明显降低高黏滞血症大鼠的全血黏度;明显延长小鼠痛阈、减少扭体次数。结论骨康宁冲剂对大鼠骨质疏松具明显的防治作用。Objective To investigate the anti-osteoporosis effect of Gukangning Granular. Methods The rat osteoporosis model was induced by vitamin A acid, and the rats blood hyperviscosity model and an- algetic model in mice were induced by dextran. Results Compared with model group, Gukangning Granu- lar increased evidently bone weight, bone mineral density, bone strength, TBV, blood calcium, bone calcium, and bone phosphorus of rats with osteoporosis, and decreased urine calcium and blood viscosity of rats with osteoporosis on blood hyperviscosity. It also increased obviously the pain threshold of mice, and decrease the frequency of mice writhing. Conclusion Gukangning Granular had remarkably anti-osteoporosis effect on rats.

关 键 词：骨康宁冲剂 骨质疏松 药效学 

分 类 号：R287.9[医药卫生—中药学]