养血清脑颗粒对自发性高血压大鼠肾脏基因表达谱的影响  

Effect of Yangxueqinnao Granule on Gene Expression of Sportaneously Hypertensire Rats

作　　者：郭志军[1] 高秀梅[1] 康利源[1] 王怡[1] 刘艳萍[1] 

机构地区：[1]天津中医药大学中医药研究中心,天津300191

出　　处：《辽宁中医药大学学报》2009年第9期172-174,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家"十五"攻关资助项目(2001BA701A07-30)

摘　　要：目的:采用基因芯片技术研究养血清脑颗粒对SHR肾脏相关基因表达的影响,探讨该药降压和减轻高血压肾损害的分子机制。方法:选取灌服养血清脑颗粒SHR,8周后处死大鼠,取出肾脏,药物组和模型组各2个样品,分别进行总RNA提取,探针标记与杂交,检测与分析。结论:养血清脑颗粒对自发性高血压大鼠(SHR)肾脏异常表达基因有一定影响。Objective ：To evaluate the effect of decreasing the blood pressure and protecting the kidney of SHR （spontaneously hypertensive rats） and study their mechanism.Methods：after taken the yangxueqingnao for 8 weeks, SHR were killed. One kidney was taken out, then northern blotting, check and analysis. Conclusion ： Some gene in kidney have been changed in the Yangxueqingnao group ,compared with the group of SHR.

关 键 词：养血清脑颗粒 SHR 肾脏保护 高血压肾损害 基因芯片 

分 类 号：R285.5[医药卫生—中药学]