结肠小袋纤毛虫体外药物急性毒杀试验  

Acute Toxicity Experiment of Medicineson Balantidium coli in Vitro

作　　者：刘翠[1] 邓书民[1] 谷伟霞[1] 袁远华[1] 胡文发[1] 王天奇[1] 

机构地区：[1]河南科技大学动物科技学院,河南洛阳471003

出　　处：《畜牧兽医杂志》2009年第5期18-20,22,共4页Journal of Animal Science and Veterinary Medicine

基　　金：河南科技大学大学生研究训练计划(SRTP)项目资助(2008041)

摘　　要：通过结肠小袋纤毛虫对甲硝唑、氟苯尼考和血虫净(三氮咪)的急性毒性试验,以机率单位法获得半数致死浓度(LC50),结果显示:甲硝唑、氟苯尼考对结肠小袋纤毛虫2 h的半数致死浓度(LC50,2 h)分别是457.8 mg/L,1705 mg/L,12 h的半数致死浓度(LC50,12 h)分别是25.64 mg/L、973.8 mg/L。血虫净(三氮咪)12h和24h半数致死浓度(LC50)分别是331.8 mg/L、295.4 mg/L。甲硝唑是杀灭结肠小袋纤毛虫的理想药物。Acute toxic experiments were carried out to test the toxicity of Metronidazole, Florfenieol, Triazoamidine on Balantidium coli in vitro. Median lethal concentrations（ LC50 values） were obtained by means of prebit method. The results demonstrated that the LC50 ,2h of Metronidazole and Floffenicol on Balantidium eoli were 457.8mg/L, 1705 mg/L. L50, 12h of Metronidazole and Floffenieol were 25.64 mg/L and 973.8rag/L, respectively. LCso, 12h and LC50 24h of Triazoamidine on Balantidium coli were 331.8 mg/L,295. 4mg/L, respectively. Mctronidazole was a perfect medicine to kill Balantidium coil.

关 键 词：结肠小袋纤毛虫 甲硝唑 氟苯尼考 血虫净(三氮咪) 机率单位法 半数致死浓度(LC50) 

分 类 号：S852.724[农业科学—基础兽医学]