Kinetic Model of the Lysogeny/Lysis Switch of Phage λ  

作　　者：丁辉 罗辽复 

机构地区：[1]Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021

出　　处：《Chinese Physics Letters》2009年第9期282-285,共4页中国物理快报（英文版）

基　　金：Supported by the National Natural Science Foundation of China under Grant Nos 90403010 and 200408020102

摘　　要：A kinetic model of the interactions between operators and regulators is developed to study the stabilities of genetic states and lysogeny/lysis switch in Eschemchia coli infected by bacteriophage lambda. Using adiabatic approximation, the kinetic evolutions of mRNA and regulator concentrations can be deduced from operators＇ equations. Furthermore, the stability of each state of the system is studied. The results show that the lysogenic state switches to the lytic state through two bifurcations： one from a single stable state to a three-point state, and the other from a three-point state to a single stable state. Then we indicate that the property of the lysogeny/lysis switch satisfies the topological characteristics theorem. Finally, the influence of the left operators on the lysogeny/lysis switch is briefly discussed. The results show that the cooperativity of the CI2 bound to left and right operators makes the lysogenic state more stable.A kinetic model of the interactions between operators and regulators is developed to study the stabilities of genetic states and lysogeny/lysis switch in Eschemchia coli infected by bacteriophage lambda. Using adiabatic approximation, the kinetic evolutions of mRNA and regulator concentrations can be deduced from operators＇ equations. Furthermore, the stability of each state of the system is studied. The results show that the lysogenic state switches to the lytic state through two bifurcations： one from a single stable state to a three-point state, and the other from a three-point state to a single stable state. Then we indicate that the property of the lysogeny/lysis switch satisfies the topological characteristics theorem. Finally, the influence of the left operators on the lysogeny/lysis switch is briefly discussed. The results show that the cooperativity of the CI2 bound to left and right operators makes the lysogenic state more stable.

分 类 号：Q939.48[生物学—微生物学] TP242[自动化与计算机技术—检测技术与自动化装置]