维奥欣对实验性动脉粥样硬化大鼠血清炎症介质的影响  

The Effect of Diosgenin Tablet on Serum Inflammation Media of Experiment Atherosclerosis Rats

作　　者：吴天敏[1] 陈金水[1] 陈成[1] 

机构地区：[1]福建医科大学附属第一医院,福州350005

出　　处：《中国中医急症》2009年第9期1471-1473,共3页Journal of Emergency in Traditional Chinese Medicine

摘　　要：目的观察维奥欣对实验性动脉粥样硬化(AS)大鼠血清肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)的影响,探讨其在AS中是否存在抗炎作用。方法60只雄性SD大鼠随机分为假手术组、模型组、阿司匹林组、维奥欣小剂量组及维奥欣大剂量组。除假手术组外,各组大鼠于饲养的第7日行经左颈总动脉主动脉内膜球囊损伤术,3个月后处死动物,留取标本,测定血脂、血清TNF-α、CRP并行颈总动脉病理形态学分析。结果与模型组比较,维奥欣大剂量组血清TG、TC、LDL-C水平显著下降,且明显低于阿司匹林组;维奥欣小剂量组与模型组无明显差异。HDL-C水平各治疗组与模型组无明显差异。颈总动脉健侧各组W/L无明显差异;与手术组相比,模型组损伤侧颈动脉内膜明显增厚,局部有斑块形成,W/L明显增大;维奥欣大、小剂量组W/L明显小于模型组,维奥欣大剂量组低于阿司匹林组,维奥欣小剂量组与阿司匹林组无显著差异。与模型组比较,维奥欣大剂量、小剂量组血清TNF-α、CRP水平显著下降,维奥欣大剂量组明显低于阿司匹林组,维奥欣小剂量组与阿司匹林组无显著差异。结论维奥欣可降低实验性AS大鼠血清TNF-α、CRP水平,抑制炎症反应达到抗AS作用。Objective： To observe the effect of Diosgenin tablet on serum tumor necrosis factor α （TNF-α） and creactive protein of experiment atherosclerosis （AS） rats and to study whether there is anti-inflammation in AS or not. Methods： 60 male SD rats were divided randomly into the group of sham operation, the group of model, the group of aspirin, the group of Diosgenin tablet in small dosage, and the group of Diosgenin tablet in large dosage. Except to the group of sham operation, other groups took operations through injuring the main artery intima of left common carotid artery by balloons on the 7th day. After 3 months, these rats were killed and then their blood lipid, TNF-α and CPR were detected. Meanwhile, the pathomorphology of common carotid artery was performed. Results： Compared with the group of model, the levels of serum TG, TC and LDL-C in the group of Diosgenin tablet in large dosage decreased significantly, and were remarkably lower than that in the group of aspirin. However, there was no significant difference between the group of Diosgenin tablet in small dosage and the group of model. The level of serum HDL-C was not significantly different between the treated groups and the model group. In the impaired side, W/L ratios of carotid artery in these groups were not obvious differences, but the intima of model group apparently thickened than the sham operation group and locally formed plaque. The W/L ratios of carotid artery in the large and small dose Weiaoxin group were much thinner than that of model group. That of the large dose Diosgenin tablet group was thinner than aspirin group. There was no significant difference between the Diosgenin tablet small dose group and the aspirin group. Compared with model group, the levels of serum TNF-A and CRP were decreased significantly in Diosgenin tablet small dose group, but these levels in Diosgenin tablet large dose group were much lower than those of aspirin group. There was no obvious difference between Diosgenin tablet small dose group and asp

关 键 词：维奥欣 动脉粥样硬化 肿瘤坏死因子Α C反应蛋白 大鼠 

分 类 号：R285.5[医药卫生—中药学]