Ge-132对人白细胞吞噬氧化活性的影响  

Ge 132 FOR PHAGOCYTIC FUNCTION OF HUMAN LEUCOCYTE INFLUEN CE

作　　者：李雪华[1] 吴华慧[1] 赵农[1] 宋慧[1] 龙盛京[1] 侯华新[1] 

机构地区：[1]广西医科大学化学教研室

出　　处：《广西医科大学学报》1998年第2期23-25,共3页Journal of Guangxi Medical University

摘　　要：目的：研究有机锗（Ｇｅ－１３２）对健康成人白细胞吞噬氧化活性的影响。方法：采用改良的人全血化学发光法测定Ｇｅ－１３２相当于在全血中所测定血浆浓度中Ｇｅ元素含量的：①１０、１００、１０００、２０００倍时白细胞的化学发光值；②１０倍加５μｇ氢化可的松时白细胞的发光值。结果：①Ｇｅ－１３２对应的锗量在低于所测定血浆浓度锗量的１００倍时，对白细胞的吞噬氧化活性具有显著激发作用，而Ｇｅ－１３２在高于所测定血浆浓度的锗量的１０００倍时，Ｇｅ－１３２对白细胞反而具有显著抑制作用；②Ｇｅ－１３２对氢化可的松不具拮抗作用。结论：此结果为临床补Ｇｅ。Objective:To investigat the effect of Ge 132 on whole blood phagocytic function of leucocyte in normal adult.Method:Human whole blood method was used to measure chemiluminescence value of leucocyte:①when Ge 132 corresponding to 10,100,1 000,2 000 times of Ge element content in the blood.②when Ge 132 corresponding to 10 times of Ge element content in the blood and adding 5μg Hydrocortisone.Results:When Ge 132 corresponding to Ge element content was below 100 times,Ge 132 increased markedly phagocytic oxidative function of leucocyte But when it was above 1 000 times of Ge content ,Ge 132 inhibited markedly phagocytic oxidative activity of leucocyte Ge 132 has not antagonistic effect on Hydrocortisone Conclusion:The results provide referential basis for the clinician how touse Ge and clarifing mechanism

关 键 词：GE-132 白细胞 化学发光法 有机锗 吞噬活性 

分 类 号：R392.12[医药卫生—免疫学] O627.42[医药卫生—基础医学]