MHC-Ⅰ链相关基因A在免疫性疾病中的研究进展  

Recent advances in the study of MICA gene in immunological diseases

作　　者：王云炎[1] 何军 侯建全[1] 

机构地区：[1]苏州大学附属第一医院泌尿外科,215006 [2]江苏省血液研究所

出　　处：《国际免疫学杂志》2009年第5期368-372,共5页International Journal of Immunology

基　　金：国家自然科学基金资助项目（30872530）;江苏省自然科学基金资助项目（BK2007056）

摘　　要：MHC-Ⅰ链相关基因A（MICA）位于人第6号染色体的MHC—Ⅰ类区域中，该基因包含6个外显子，编码的蛋白分子结构域与经典的Ⅰ类分子α链相似，包括胞外结构域（α1、α2与α3）、跨膜区和胞质区，但不含β2微球蛋白。MICA表达于内皮细胞、上皮细胞、单核细胞、成纤维细胞以及大多数上皮性肿瘤细胞表面，但在CD4^＋T细胞、CD8^＋T细胞和CD19^＋细胞不表达。MICA在肾脏等器官移植排斥反应和移植物存活率有重要的相关性，其抗体阳性者预后较差。MICA在肿瘤、自身免疫性疾病、感染性疾病的发生、发展过程中起着独特的作用。Major histocompatibility complex class Ⅰ chain related gene A（MICA） is located within the MHC class Ⅰ region of chromosome 6, including six exons. The MICA locus encodes membrane-bound polypeptides which are similar to the classic class Ⅰ molecules with three extracellular domains （α1, α2, and α3）, a transmembrane domain, and a cytoplasmic tail. MICA are not associated with β2-microglobulin. MICA is expressed in endothelial cells, monocytes, epithelial cells, fibroblasts, and many epithelial tumor cell lines, but not in peripheral blood CD4^＋ , CD8^＋ , or CD19^＋ lymphocytes. The transplantation rejection and graft survival rates in kidney and other organ are closely associated with MICA. The recipients with anti-MICA antibodies have poor prognosis. MICA also plays a unique role in the development process of tumors, autoimmune diseases, .and infectious diseases.

关 键 词：MHC-Ⅰ链相关基因A 器官移植 自身免疫性疾病 感染性疾病 

分 类 号：R593[医药卫生—内科学]