辅助T细胞分化的表观遗传学调控  

Epigenetic regulation of T helper cell differentiation

作　　者：来利华[1] 王青青[1] 

机构地区：[1]浙江大学医学院免疫学研究所,杭州310058

出　　处：《国际免疫学杂志》2009年第5期382-387,共6页International Journal of Immunology

基　　金：国家自然科学基金资助项目（30872377）

摘　　要：在抗原的刺激下，CD4^＋辅助性T细胞（Th细胞）可分化为不同的细胞亚群以对抗不同的外界环境。Th细胞的分化主要受细胞因子、细胞特异性转录因子等调控。近年来研究发现，DNA甲基化、组蛋白修饰以及染色质重塑等表观遗传学修饰能调控相关基因的表达，使Th细胞分化成稳定的亚群，发挥相应的功能。同时，这些表观遗传学修饰机制在赋予Th细胞亚群可遗传性、可塑性等方面也发挥着重要的作用。Naive CD4^＋ T cells can differentiate into different effector cells under the stimulation of antigens in response to various environments. The specification of T helper cell subsets is controlled by the networks of lineage specific, cytokines and transcription factors. In recent years, researches have showed that epigenetic processes such as DNA methylation, histone modifications and chromatin remodeling can regulate the expression of some related genes which govern the fate and function of T helper ceils. These epigenetic processes also play important roles in the heritability and plasticity of T helper cell lineage.

关 键 词：TH细胞 分化 表观遗传学 

分 类 号：R392.1[医药卫生—免疫学]